Conspectus Compounds containing a difluoromethylene unit have gained increasing
attention due to their utility in drug design. Classic methods for the synthesis of these …

Currently, the chemistry of organofluorine compounds is a leading and rapidly developing
area of organic chemistry. Fluorine present in a molecule largely determines its specific …

The use of metal catalysts to produce and control the reactivity of carbenes has long offered
a powerful approach to organic synthesis; however, difluorocarbene transfer catalysed by …

The challenges of the modern society and the growing demand of high-technology sectors
of industrial production bring about a new phase in the development of organic synthesis. A …

The involvement of manganese radical for halogen atom transfer (XAT) reactions has been
esteemed as one reliable method but encountered with limited catalytic models. In this …

We report the Pd-catalyzed α-arylation of α, α-difluoroketones with aryl and heteroaryl
bromides and chlorides catalyzed by an air-and moisture-stable palladacyclic complex …

Transition-metal-mediated fluoroalkylation is a hot research topic in current organofluorine
chemistry. In the past five years, due to the development of new perfluoroalkylation reagents …

Cross-coupling between difluorocarbene and carbene-derived intermediates generated
from diazocompounds was developed to give gem-difluoroolefins, which constitutes a fast …

A wide range of air‐stable, solid, polyfunctional aryl and heteroarylzinc pivalates were
efficiently prepared by either magnesium insertion or Hal/Mg exchange followed by …

A method for nucleophilic difluoromethylation of reactive Michael acceptors, aldehydes, and
azomethines is described. The reaction is performed using the readily available and air …