Immune evasion and metabolic reprogramming are two fundamental hallmarks of cancer.
Interestingly, lactate closely links them together. However, lactate has long been recognized …

Vascular smooth muscle cells (VSMCs) are the fundamental component of the medial layer
of arteries and are essential for arterial physiology and pathology. It is becoming …

Augmented glycolysis due to metabolic reprogramming in lung myofibroblasts is critical to
their profibrotic phenotype. The primary glycolysis byproduct, lactate, is also secreted into …

Rationale: Patients with elevated levels of lipoprotein (a)[Lp (a)] are hallmarked by
increased metabolic activity in the arterial wall on positron emission tomography/computed …

Increased glycolysis in the lung vasculature has been connected to the development of
pulmonary hypertension (PH). We therefore investigated whether glycolytic regulator 6 …

Objectives High‐mobility group box‐1 (HMGB1) and aberrant mitochondrial fission
mediated by excessive activation of GTPase dynamin‐related protein 1 (Drp1) have been …

Rationale: CD47 plays a vital role in the immune escape of tumor cells, but its role in
regulating immune-unrelated biological processes such as proliferation and metastasis …

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

Increased mitochondrial reactive oxygen species (mROS) and glycolysis have been
established in pulmonary hypertension (PH). However, the effect of elevated mROS on …

Background Pulmonary hypertension (PH) associated to idiopathic pulmonary fibrosis (IPF)
portends a poor prognosis. IL-11 has been implicated in fibrotic diseases, but their role on …