Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

[HTML][HTML] MSC based gene delivery methods and strategies improve the therapeutic efficacy of neurological diseases

H Zhou, Y He, W Xiong, S Jing, X Duan, Z Huang… - Bioactive materials, 2023 - Elsevier
Mesenchymal stem cells (MSCs) are promising seed cells for neural regeneration therapy
owing to their plasticity and accessibility. They possess several inherent characteristics …

Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow

D Baksh, R Yao, RS Tuan - Stem cells, 2007 - academic.oup.com
Human umbilical cord perivascular cells (HUCPVCs) have been shown to have a high
proliferative potential and the capacity to differentiate into an osteogenic phenotype …

Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25 into CD25+ T regulatory cells

A Curti, S Pandolfi, B Valzasina, M Aluigi, A Isidori… - Blood, 2007 - ashpublications.org
Abstract Indoleamine 2, 3-dioxygenase (IDO) is a novel immunosuppressive agent
expressed in some subsets of normal and neoplastic cells, including acute myeloid …

Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles

F Yang, SW Cho, SM Son… - Proceedings of the …, 2010 - National Acad Sciences
Stem cells hold great potential as cell-based therapies to promote vascularization and tissue
regeneration. However, the use of stem cells alone to promote angiogenesis remains limited …

New opportunities: the use of nanotechnologies to manipulate and track stem cells

L Ferreira, JM Karp, L Nobre, R Langer - Cell stem cell, 2008 - cell.com
Nanotechnologies are emerging platforms that could be useful in measuring, understanding,
and manipulating stem cells. Examples include magnetic nanoparticles and quantum dots …

Polyblend nanofibers for biomedical applications: perspectives and challenges

J Gunn, M Zhang - Trends in biotechnology, 2010 - cell.com
Advances in disease treatment and tissue regeneration are buoyed by new, multifaceted
materials that emulate and coercively interact with the local microenvironment. Polyblend …

Physical non-viral gene delivery methods for tissue engineering

AJ Mellott, ML Forrest, MS Detamore - Annals of biomedical engineering, 2013 - Springer
The integration of gene therapy into tissue engineering to control differentiation and direct
tissue formation is not a new concept; however, successful delivery of nucleic acids into …

Introducing a single‐cell‐derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer

W Böcker, Z Yin, I Drosse, F Haasters… - Journal of cellular …, 2008 - Wiley Online Library
Human mesenchymal stem cells (hMSCs) can be readily isolated from bone marrow and
differentiate into multiple tissues, making them a promising target for future cell and gene …

Non-viral gene delivery to mesenchymal stem cells: methods, strategies and application in bone tissue engineering and regeneration

JL Santos, D Pandita, J Rodrigues… - Current gene …, 2011 - ingentaconnect.com
Mesenchymal stem cells (MSCs) can be isolated from several tissues in the body, have the
ability to selfrenewal, show immune suppressive properties and are multipotent, being able …