The Drosophila embryonic central nervous system (CNS) is a complex organ consisting of∼
15,000 neurons and glia that is generated in∼ 1 day of development. For the past 40 years …

Mitochondrial rho GTPase (Miro) is a mitochondrial outer membrane protein containing two
GTPase domains and two helix-loop-helix Ca2+-binding domains called EF hands …

Adult stem cells reactivate from quiescence to maintain tissue homeostasis and in response
to injury. How the underlying regulatory signals are integrated is largely unknown …

Cell commitment to tumourigenesis and the onset of uncontrolled growth are critical
determinants in cancer development but the early events directing tumour initiating cell (TIC) …

The extension of long slender axons is a key process of neuronal circuit formation, both
during brain development and regeneration. For this, growth cones at the tips of axons are …

Disturbance in the neuronal network leads to instability in the microtubule (MT) railroad of
axons, causing hindrance in the intra-axonal transport and making it difficult to re-establish …

Gliomas are heterogeneous neoplasms, classified into grade I to IV according to their
malignancy and the presence of specific histological/molecular hallmarks. The higher grade …

We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …

Neurons have differential and fluctuating energy needs across distinct cellular
compartments, shaped by brain electrochemical activity associated with cognition. In vitro …

Repair after traumatic injury often starts with mitotic activation around the lesion edges. Early
midline cells in the Drosophila embryonic CNS can enter into division following the traumatic …