Current status and applications of genome-scale metabolic models
Genome-scale metabolic models (GEMs) computationally describe gene-protein-reaction
associations for entire metabolic genes in an organism, and can be simulated to predict …
associations for entire metabolic genes in an organism, and can be simulated to predict …
Recent advances in metabolic engineering of Saccharomyces cerevisiae: new tools and their applications
Metabolic engineering aims to develop efficient cell factories by rewiring cellular
metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae …
metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae …
A consensus S. cerevisiae metabolic model Yeast8 and its ecosystem for comprehensively probing cellular metabolism
Genome-scale metabolic models (GEMs) represent extensive knowledgebases that provide
a platform for model simulations and integrative analysis of omics data. This study …
a platform for model simulations and integrative analysis of omics data. This study …
A community-driven global reconstruction of human metabolism
Multiple models of human metabolism have been reconstructed, but each represents only a
subset of our knowledge. Here we describe Recon 2, a community-driven, consensus' …
subset of our knowledge. Here we describe Recon 2, a community-driven, consensus' …
The yeast deletion collection: a decade of functional genomics
The yeast deletion collections comprise> 21,000 mutant strains that carry precise start-to-
stop deletions of∼ 6000 open reading frames. This collection includes heterozygous and …
stop deletions of∼ 6000 open reading frames. This collection includes heterozygous and …
Optimizing genome-scale network reconstructions
Optimizing genome-scale network reconstructions | Nature Biotechnology Skip to main content
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A genome-scale metabolic model of Saccharomyces cerevisiae that integrates expression constraints and reaction thermodynamics
Eukaryotic organisms play an important role in industrial biotechnology, from the production
of fuels and commodity chemicals to therapeutic proteins. To optimize these industrial …
of fuels and commodity chemicals to therapeutic proteins. To optimize these industrial …
Genome-scale modeling of yeast metabolism: retrospectives and perspectives
Yeasts have been widely used for production of bread, beer and wine, as well as for
production of bioethanol, but they have also been designed as cell factories to produce …
production of bioethanol, but they have also been designed as cell factories to produce …
Revising the representation of fatty acid, glycerolipid, and glycerophospholipid metabolism in the consensus model of yeast metabolism
HW Aung, SA Henry, LP Walker - Industrial biotechnology, 2013 - liebertpub.com
Genome-scale metabolic models are built using information from an organism's annotated
genome and, correspondingly, information on reactions catalyzed by the set of metabolic …
genome and, correspondingly, information on reactions catalyzed by the set of metabolic …
Improving metabolic flux predictions using absolute gene expression data
Background Constraint-based analysis of genome-scale metabolic models typically relies
upon maximisation of a cellular objective function such as the rate or efficiency of biomass …
upon maximisation of a cellular objective function such as the rate or efficiency of biomass …