Obesity and associated chronic inflammation were shown to facilitate breast cancer (BC)
growth and metastasis. Leptin, adiponectin, estrogen, and several pro-inflammatory …

There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer.
S1P regulates processes such as inflammation, which can drive tumorigenesis; …

Sphingolipids are critical regulators of tumor microenvironments and play an important role
in estrogen-dependent cancers. Estrogen and estrogen metabolites were found to be …

Sphingolipids have emerged as bioeffector molecules, controlling various aspects of cell
growth and proliferation in cancer, which is becoming the deadliest disease in the world …

Inflammatory gastrointestinal (GI) diseases and malignancies are associated with growing
morbidity and cancer-related mortality worldwide. GI tumor and inflammatory cells contain …

Sphingosine 1-phosphate (S1P), a potent sphingolipid mediator produced by sphingosine
kinase isoenzymes (SphK1 and SphK2), regulates diverse cellular processes important for …

Sphingolipids are components of all eukaryotic cells that play important roles in a wide
variety of biological processes. Ceramides and sphingosine-1-phosphate (S1P) are …

FTY720 (Fingolimod) is a clinically approved immunomodulating therapy for multiple
sclerosis that sequesters T-cells to lymph nodes through functional antagonism of …

Lipid phosphate phosphatases (LPPs) are a group of enzymes that belong to a
phosphatase/phosphotransferase family. Mammalian LPPs consist of three isoforms: LPP1 …

Sphingolipid metabolites, such as ceramide, sphingosine and sphingosine-1-phosphate
(S1P), play many important roles in cellular activities. Ceramide and sphingosine inhibit cell …