Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides
produced by interrupted translation. Central players in RQC are the human ribosome-and …

The stalling of ribosomes during protein synthesis results in the production of truncated
polypeptides that can have deleterious effects on cells and therefore must be eliminated. In …

Therapeutic mRNAs and vaccines are being developed for a broad range of human
diseases, including COVID-19. However, their optimization is hindered by mRNA instability …

The annotation of the mammalian protein-coding genome is incomplete. Arbitrary size
restriction of open reading frames (ORFs) and the absolute requirement for a methionine …

Ribosomes that stall while translating cytosolic proteins are incapacitated by incomplete
nascent chains, termed “arrest peptides”(APs) that are destroyed by the ubiquitin …

Ribosome movement is not always smooth and is rather often impeded. For ribosome
pauses, fundamental issues remain to be addressed, including where ribosomes pause on …

Similar to many other biological molecules, RNA is vulnerable to chemical insults from
endogenous and exogenous sources. Noxious agents such as reactive oxygen species or …

Ribosome-associated quality control (RQC) pathways protect cells from toxicity caused by
incomplete protein products resulting from translation of damaged or problematic mRNAs …

Translating ribosomes slow down or completely stall when they encounter obstacles on
mRNAs. Such events can lead to ribosomes colliding with each other and forming …

Ribosomes that become stalled on truncated or damaged mRNAs during protein synthesis
must be rescued for the cell to survive. Bacteria have evolved a diverse array of rescue …