Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain
homeostatic functions and mediate pathogenic mechanisms, including the inflammatory …

It is now more than 15 years since the molecular structures of the major prostanoid receptors
were elucidated. Since then, substantial progress has been achieved with respect to …

Inflammation has been described for two millennia, but cellular aspects and the paradigm
involving different mediators have been identified in the recent century. Two main groups of …

Prostaglandins are lipid-derived autacoids that modulate many physiological systems
including the CNS, cardiovascular, gastrointestinal, genitourinary, endocrine, respiratory …

The isoprostanes are a unique series of prostaglandin-like compounds formed in vivo via a
non-enzymatic mechanism involving the free radical-initiated peroxidation of arachidonic …

Oxidative stress plays a major role in diabetes as well as in Alzheimer's disease and other
related neurological diseases. Intracellular oxidative stress arises due to the imbalance in …

Periparturient dairy cows experience an increased incidence and severity of several
inflammatory-based diseases such as mastitis and metritis. Factors associated with the …

The cyclooxygenases COX-1 and COX-2 catalyze the first committed step of prostaglandin
synthesis from arachidonic acid. Previous studies in rodent stroke models have shown that …

Epidemiological studies demonstrate that chronic use of nonsteroidal anti-inflammatory
drugs (NSAIDs) in normal aging populations reduces the risk of developing Alzheimer's …