Flavonoids as alpha-glucosidase inhibitors: Mechanistic approaches merged with enzyme kinetics and molecular modelling

D Şöhretoğlu, S Sari - Phytochemistry Reviews, 2020 - Springer
Diabetes mellitus is a major, global public health problem. α-Glucosidase inhibitors are one
of the most widely used classes of oral antidiabetics. In addition to other pharmaceutical …

Application of carbohydrates in approved small molecule drugs: A review

H Jiang, X Qin, Q Wang, Q Xu, J Wang, Y Wu… - European Journal of …, 2021 - Elsevier
Carbohydrates are an important energy source and play numerous key roles in all living
organisms. Carbohydrates chemistry involved in diagnosis and treatment of diseases has …

Antioxidant and Anti-α-Glucosidase Activities of Various Solvent Extracts and Major Bioactive Components from the Fruits of Crataegus pinnatifida

YT Lin, HR Lin, CS Yang, CC Liaw, PJ Sung, YH Kuo… - Antioxidants, 2022 - mdpi.com
Crataegus pinnatifida is used to treat various diseases, including indigestion, congestive
heart failure, hypertension, atherosclerosis, and myocardial dysfunction. We evaluated …

Synthesis, crystal structure, DFT, α-glucosidase and α-amylase inhibition and molecular docking studies of (E)-N'-(4-chlorobenzylidene)-5-phenyl-1H-pyrazole-3 …

K Karrouchi, S Fettach, B Tüzün, S Radi… - Journal of Molecular …, 2021 - Elsevier
In this work, a novel crystal ie (E)-N'-(4-chlorobenzylidene)-5-phenyl-1H-pyrazole-3-
carbohydrazide has been synthesized and characterized using various spectroscopic …

Comparison of Various Solvent Extracts and Major Bioactive Components from Portulaca oleracea for Antioxidant, Anti-Tyrosinase, and Anti-α-Glucosidase Activities

WC Chen, SW Wang, CW Li, HR Lin, CS Yang, YC Chu… - Antioxidants, 2022 - mdpi.com
Portulaca oleracea is a well-known species for traditional medicine and food homology in
Taiwan. In traditional medicine, P. oleracea is also used to treat gastrointestinal disorders …

Discovery of new α-glucosidase inhibitors: Structure-based virtual screening and biological evaluation

SK Liu, H Hao, Y Bian, YX Ge, S Lu, HX Xie… - Frontiers in …, 2021 - frontiersin.org
α-Glycosidase inhibitors could inhibit the digestion of carbohydrates into glucose and
promote glucose conversion, which have been used for the treatment of type 2 diabetes. In …

Sage (Salvia macrochlamys): LC-HRMS for phytochemical analysis, cytotoxicity, enzyme inhibition, antioxidant activity, molecular docking and molecular dynamics …

H Kızıltaş, AB Ortaakarsu, Z Bingöl… - Plant Biosystems-An …, 2024 - Taylor & Francis
This study primarily aims to evaluate the phenolic content and biological activity of Salvia
macrochlamys both in vitro and in silico. The antioxidant activities of Salvia macrochlamys …

Antidiabetic potential of novel 1, 3, 5-trisubstituted-2-thioxoimidazloidin-4-one analogues: Insights into α-glucosidase, α-amylase, and antioxidant activities

SM Khirallah, HMM Ramadan, HAA Aladl, NO Ayaz… - Pharmaceuticals, 2022 - mdpi.com
As the ninth leading cause of death globally, diabetes mellitus (DM) is considered to be the
worst chronic metabolic disease requiring an enormous need for healthcare with over 578 …

Advances in the natural α‐glucosidase inhibitors

D Şöhretoğlu, G Renda, R Arroo, J Xiao, S Sari - Efood, 2023 - Wiley Online Library
Abstract α‐Glucosidase (AG) inhibitors, one of the classes of oral antidiabetics used to treat
type 2 diabetes mellitus, delay digestion and absorption of glucose, which in turn, has a …

Synthesis of indole derivatives as diabetics II inhibitors and enzymatic kinetics study of α-glucosidase and α-amylase along with their in-silico study

M Taha, AS Alrashedy, NB Almandil, N Iqbal… - International Journal of …, 2021 - Elsevier
In this study, we have investigated a series of indole-based compounds for their inhibitory
study against pancreatic α-amylase and intestinal α-glucosidase activity. Inhibitors of …