Background Female sex workers are a population who are at heightened risk of HIV
infection secondary to biological, behavioural, and structural risk factors. However, three …

Sex work remains an important contributor to HIV transmission within early, advanced and
regressing epidemics in sub-Saharan Africa, but its social and behavioral underpinnings …

Antibodies capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the
HIV-1 envelope, but the mechanism of their elicitation has been unclear. Here we define the …

Although antiretroviral therapy (ART) is highly effective at suppressing HIV-1 replication, the
virus persists as a latent reservoir in resting CD4+ T cells during therapy. This reservoir …

An understanding of how broadly neutralizing activity develops in HIV-1-infected individuals
is needed to guide vaccine design and immunization strategies. Here we used a large panel …

The epitopes defined by HIV-1 broadly neutralizing antibodies (bNAbs) are valuable
templates for vaccine design, and studies of the immunological development of these …

Sex work occurs in many forms and sex workers of all genders have been affected by HIV
epidemics worldwide. The determinants of HIV risk associated with sex work occur at …

Background Epidemiological data show substantial variation in the risk of HIV infection
between communities within African countries. We hypothesised that focusing appropriate …

Neutralizing antibodies are likely to play a crucial part in a preventative HIV-1 vaccine.
Although efforts to elicit broadly cross-neutralizing (BCN) antibodies by vaccination have …

Given the absence of an effective vaccine for protection against HIV-1 infection, passive
immunization strategies that utilize potent broadly neutralizing antibodies (bnAbs) to block …