Control of tissue development by morphogens
Intercellular signaling molecules, known as morphogens, act at a long range in developing
tissues to provide spatial information and control properties such as cell fate and tissue …
tissues to provide spatial information and control properties such as cell fate and tissue …
Morphogen rules: design principles of gradient-mediated embryo patterning
The Drosophila blastoderm and the vertebrate neural tube are archetypal examples of
morphogen-patterned tissues that create precise spatial patterns of different cell types. In …
morphogen-patterned tissues that create precise spatial patterns of different cell types. In …
Context-dependent TGFβ family signalling in cell fate regulation
L Richardson, SG Wilcockson, L Guglielmi… - … Reviews Molecular Cell …, 2023 - nature.com
The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved
cytokines whose signalling modulates cell fate decision-making across varying cellular …
cytokines whose signalling modulates cell fate decision-making across varying cellular …
[HTML][HTML] CRISPR-Cas13d induces efficient mRNA knockdown in animal embryos
G Kushawah, L Hernandez-Huertas, JAN Del Prado… - Developmental Cell, 2020 - cell.com
Early embryonic development is driven exclusively by maternal gene products deposited
into the oocyte. Although critical in establishing early developmental programs, maternal …
into the oocyte. Although critical in establishing early developmental programs, maternal …
Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids
During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers—
endoderm, mesoderm and ectoderm, which eventually form the entire embryo. Decades of …
endoderm, mesoderm and ectoderm, which eventually form the entire embryo. Decades of …
[HTML][HTML] Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming
Embryo development requires biochemical signalling to generate patterns of cell fates and
active mechanical forces to drive tissue shape changes. However, how these processes are …
active mechanical forces to drive tissue shape changes. However, how these processes are …
Transgenic fluorescent zebrafish lines that have revolutionized biomedical research
CP Choe, SY Choi, Y Kee, MJ Kim, SH Kim… - Laboratory Animal …, 2021 - Springer
Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …
vertebrate model organism in more than 40,000 biomedical research studies. Especially …
Morphogen interpretation: concentration, time, competence, and signaling dynamics
Tissue patterning during animal development is orchestrated by a handful of inductive
signals. Most of these developmental cues act as morphogens, meaning they are locally …
signals. Most of these developmental cues act as morphogens, meaning they are locally …
TGF-β family signaling in early vertebrate development
TGF-β family ligands function in inducing and patterning many tissues of the early vertebrate
embryonic body plan. Nodal signaling is essential for the specification of mesendodermal …
embryonic body plan. Nodal signaling is essential for the specification of mesendodermal …
Patterning principles of morphogen gradients
MF Simsek, EM Özbudak - Open Biology, 2022 - royalsocietypublishing.org
Metazoan embryos develop from a single cell into three-dimensional structured organisms
while groups of genetically identical cells attain specialized identities. Cells of the …
while groups of genetically identical cells attain specialized identities. Cells of the …