Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Sexually dimorphic traits are common among mammals and are specified during
development through the deployment of sex-specific genetic programs. Because little is …

Background Higher-order chromatin structure is often perturbed in cancer and other
pathological states. Although several genetic and epigenetic differences have been charted …

In estrogen receptor (ER)–negative breast cancer, high tumor glucocorticoid receptor (GR)
expression has been associated with a relatively poor outcome. In contrast, using a meta …

Whereas the actions of enhancers in gene transcriptional regulation are well established,
roles of JmjC-domain-containing proteins in mediating enhancer activation remain poorly …

Abstract Gender influences Papillary Thyroid Cancer (PTC) with an incidence of 3: 1 when
comparing women to men with different aggressiveness. This gender discrepancy suggests …

Multiple mechanisms of epigenetic control that include DNA methylation, histone
modification, noncoding RNAs, and mitotic gene bookmarking play pivotal roles in stringent …

In the cell nucleus, each chromosome is confined to a chromosome territory. This spatial
organization of chromosomes plays a crucial role in gene regulation and genome stability …

Resistance to hormonal therapies is a major clinical problem in the treatment of estrogen
receptor α–positive (ERα+) breast cancers. Epigenetic marks, namely DNA methylation of …