The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …

Rapid advancements in artificial intelligence (AI) have enabled breakthroughs across many
scientific disciplines. In organic chemistry, the challenge of planning complex multistep …

γ-Amino acids have attracted considerable attention as biologically active compounds in the
central nervous system (CNS) of mammals. Over the last few years, significant interest in the …

Baclofen, β-(4-chlorophenyl)-γ-aminobutyric acid, holds a unique position in neuroscience,
remaining the only US Food and Drug Administration (FDA) approved GABAB agonist …

The two-step flow asymmetric synthesis of chiral γ-nitrobutyric acids as key intermediates of
the GABA analogues baclofen, phenibut, and fluorophenibut is reported on a multigram …

Highly enantioselective biomimetic Michael addition reactions of malonic acid half thioesters
(MAHTs) to a variety of nitroolefins, affording the optically active γ‐amino acid precursors …

Asymmetric Synthesis of β-Substituted γ-Lactams via Rhodium/Diene-Catalyzed 1,4-Additions:
Application to the Synthesis of (R)-Baclofen and (R)-Rolipram | Organic Letters ACS ACS …

Highly Enantioselective Organocatalytic Conjugate Addition of Nitromethane to α,β╒Unsaturated
Aldehydes: Threeâ• Page 1 DOI: 10.1002/adsc.200700353 Highly Enantioselective …

A Rh/bisphosphine-thiourea (ZhaoPhos) catalytic system has been identified for the
straightforward asymmetric synthesis of chiral γ-lactams. A variety of NH free α, β …

The synthetic potential of highly directional formal insertion of a carbene between carbon
and hydrogen of a carbon–hydrogen bond has recently been developed for intramolecular …