The CRISPR/Cas9 system is a rapid, simple, and often extremely efficient gene editing
method. This method has been used in a variety of organisms and cell types over the past …

Spermatogonial stem cells (SSCs) are the most primitive spermatogonia in the testis and
have an essential role to maintain highly productive spermatogenesis by self-renewal and …

Genome editing is a powerful new tool for making precise alterations to an organism's
genetic material. Recent scientific advances have made genome editing more efficient …

Meiosis is the chromosomal foundation of reproduction, with errors in this important process
leading to aneuploidy and/or infertility. In this review celebrating the 50th anniversary of the …

Infertility is a prevalent condition that has insidious impacts on the infertile individuals, their
families, and society, which extend far beyond the inability to have a biological child …

Spermatogenesis is a complex, multistep process that maintains male fertility and is
sustained by rare germline stem cells. Spermatogenic progression begins with …

Background The development of a safe, effective, reversible, non-hormonal contraceptive
method for men has been an ongoing effort for the past few decades. However, despite …

The recent advent of CRISPR/Cas9-mediated genome editing has created a wave of
excitement across the scientific research community, carrying the promise of simple and …

Historically, the rat has been the preferred animal model for behavioral studies. Limitations
in genome modification have, however, caused a lag in their use compared to the bevy of …

Genetic engineering of model organisms and cultured cells has for decades provided
important insights into the mechanisms underlying cardiovascular development and …