ABSTRACT Homologous to E6AP C-terminus (HECT) E3 ubiquitin ligases play a critical role
in various cellular pathways, including but not limited to protein trafficking, subcellular …

E3 ligases are a class of enzymes that can transfer ubiquitin to substrates for their
degradation, which are of importance in cellular homeostasis. Since many oncogenic or …

HECT-family E3 ligases ubiquitinate protein substrates to control virtually every eukaryotic
process and are misregulated in numerous diseases. Nonetheless, understanding of HECT …

Smad ubiquitination regulatory factor 1 (Smurf1) and Smurf2 are HECT-type E3 ubiquitin
ligases, and both Smurfs were initially identified to regulate Smad protein stability in the TGF …

Protein ubiquitination is an evolutionary conserved highly-orchestrated enzymatic cascade
essential for normal cellular functions and homeostasis maintenance. This pathway relies on …

In addition to allelic mutations, cancers are known to harbor alterations in their chromatin
landscape. Here we show that genomic ablation of Smad ubiquitin regulatory factor 2 …

Breast cancer cells release a large quantity of biocargo‐bearing extracellular vesicles (EVs),
which mediate intercellular communication within the tumour microenvironment and …

Fucoidan, a polysaccharide extracted from brown seaweeds, reduces tumor cell
proliferation. Fucoidan inhibits the growth of breast cancer cells such as 4T1 and MDA-MB …

Background Growing evidence indicates that miR-200c is involved in carcinogenesis and
tumor progression in non-small-cell lung cancer (NSCLC). However, its precise biological …

SMURF2 is a member of the HECT family of E3 ubiquitin ligases that have important roles as
a negative regulator of transforming growth factor‐β (TGF‐β) signaling through ubiquitin …