Diabetic kidney disease, a leading cause of end-stage renal disease, has become a serious
public health problem worldwide and lacks effective therapies. Autophagy is a highly …

Background: Diabetes is one of the most challenging health problems in 21st century. It is a
group of endocrine-metabolic disorder characterized by high glucose level (hyperglycemia) …

Podocytes are known to play a determining role in the progression of proteinuric kidney
disease. N6-methyladenosine (m6A), as the most abundant chemical modification in …

Podocyte injury and loss contribute to the progression of glomerular diseases, including
diabetic kidney disease. We previously found that the glomerular expression of Sirtuin-1 …

Cardiovascular diseases (CVDs) are still the main cause of morbidity and mortality
worldwide and include a group of disorders varying from vasculature, myocardium …

Podocytes are a crucial cellular component in maintaining the glomerular filtration barrier,
and their injury is the major determinant in the development of albuminuria and diabetic …

Osteoarthitis (OA) is the most common aging-related joint pathology; the aging process
results in changes to joint tissues that ultimately contribute to the development of OA …

Age-related disorders such as chronic kidney disease (CKD) are increasingly prevalent
globally and pose unprecedented challenges. In many aspects, CKD can be viewed as a …

Type 2 diabetic mellitus is a multifactorial metabolic disorder affecting huge population
around the world. This indicates that there is an urgent unmet need of cost effective, new …

Background Diabetic kidney disease is a renal microvascular disease caused by diabetes,
known as one of the most serious and lethal complications of diabetes. Early renal …