Emerging extracellular molecular targets for innovative pharmacological approaches to resistant Mtb infection

A Italia, MM Shaik, F Peri - Biomolecules, 2023 - mdpi.com
Emerging pharmacological strategies that target major virulence factors of antibiotic-
resistant Mycobacterium tuberculosis (Mtb) are presented and discussed. This review is …

Specific Interaction between Mycobacterium tuberculosis Lipoprotein‐derived Peptides and Target Cells Inhibits Mycobacterial Entry In Vitro

M Ocampo, H Curtidor, M Vanegas… - Chemical biology & …, 2014 - Wiley Online Library
Tuberculosis (TB) continues being one of the diseases having the greatest mortality rates
around the world, 8.7 million cases having been reported in 2011. An efficient vaccine …

[HTML][HTML] An antigen-specific, four-color, B-cell FluoroSpot assay utilizing tagged antigens for detection

P Jahnmatz, T Bengtsson, B Zuber, A Färnert… - Journal of …, 2016 - Elsevier
The FluoroSpot assay, a variant of ELISpot utilizing fluorescent detection, has so far been
used primarily for assessment of T cells, where simultaneous detection of several cytokines …

Mce4F Mycobacterium tuberculosis protein peptides can inhibit invasion of human cell lines

DC Rodríguez, M Ocampo, Y Varela… - Pathogens and …, 2015 - academic.oup.com
This work was aimed at studying the Mycobacterium tuberculosis H37Rv Rv3494c protein,
taking into account that it belongs to the mammalian cell entry family (mce) which is thought …

In silico epitope analysis of unique and membrane associated proteins from Mycobacterium avium subsp. paratuberculosis for immunogenicity and vaccine evaluation

P Carlos, V Roupie, S Holbert, F Ascencio… - Journal of Theoretical …, 2015 - Elsevier
Mycobacterium avium subsp. paratuberculosis (MAP) is the etiologic agent of
paratuberculosis disease affecting ruminants worldwide. The aim of this study was to identify …

[HTML][HTML] Towards designing a synthetic antituberculosis vaccine: The Rv3587c peptide inhibits mycobacterial entry to host cells

ML Carabali-Isajar, M Ocampo, DC Rodriguez… - Bioorganic & medicinal …, 2018 - Elsevier
Mycobacterium tuberculosis is considered one of the most successful pathogens in the
history of mankind, having caused 1.7 million deaths in 2016. The amount of resistant and …

Mycobacterium tuberculosis H37Rv LpqG Protein Peptides Can Inhibit Mycobacterial Entry through Specific Interactions

CD Sánchez-Barinas, M Ocampo, M Vanegas… - Molecules, 2018 - mdpi.com
Mycobacterium tuberculosis is the causative agent of tuberculosis, a disease causing major
mortality worldwide. As part of a systematic methodology for studying M. tuberculosis surface …

Cell‐Peptide Specific Interaction Can Inhibit Mycobacterium tuberculosis H37Rv Infection

DC Rodríguez, M Ocampo, C Reyes… - Journal of cellular …, 2016 - Wiley Online Library
Studying proteins from the M. tuberculosis H37Rv envelop is important for understanding
host‐pathogen interaction regarding bacterial infection and survival within a host; such …

Identifying and characterising PPE7 (Rv0354c) high activity binding peptides and their role in inhibiting cell invasion

DP Díaz, M Ocampo, Y Varela, H Curtidor… - Molecular and Cellular …, 2017 - Springer
This study was aimed at characterising the PPE7 protein from the PE/PPE protein family.
The presence and transcription of the rv0354c gene in the Mycobacterium tuberculosis …

[HTML][HTML] Antibodies targeting Mycobacterium tuberculosis peptides inhibit mycobacterial entry to infection target cells

ML Carabali-Isajar, M Ocampo, Y Varela… - International Journal of …, 2020 - Elsevier
The humoral immunity regarding tuberculosis can contribute towards controlling the
mycobacteria and the disease. Antigens mediating such type of immunity should thus be …