Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been
reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic …

The short-term immediate release of supersaturated drug-delivery systems (SDDSs)
presents an interesting process that can be tailored to multi-stage release events including …

Combinatorial chemistry and drug design have produced more lipophilic, heavier, and less
water soluble drugs in recent years. It is more difficult to find the best drug delivery system for …

Objective: Simvastatin is a bioactive compound belonging to the class II Biopharmaceutic
Classification System (BSC), which has high permeability but low solubility. The low …

Abstract Formulation scientists continue to face challenges in improving the oral
bioavailability of medications administered in solid dosage forms due to limited solubility of …

The article combines recent literature reviews on solid dispersion technology to improve the
solubility of poorly water-soluble drugs with a particular focus on different solid dispersion …