Electronic health records (EHRs) are a rich source of data for researchers, but extracting
meaningful information out of this highly complex data source is challenging. Phecodes …

The development and progression of cardiovascular disease (CVD) can mainly be attributed
to the narrowing of blood vessels caused by atherosclerosis and thrombosis, which induces …

The gene encoding proprotein convertase subtilisin/kexin type 9 (PCSK9) and its protein
product have been widely studied for their role in cholesterol and lipid metabolism. PCSK9 …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has long been studied in the liver due
to its regulation of plasma low-density lipoprotein cholesterol (LDL-C) and its causal role in …

Background: Proprotein convertase subtilisin kexin type 9 inhibitors (PCSK9i) lower LDL-
cholesterol and slow atherosclerosis preventing cardiovascular events. While it is known …

Diabetes mellitus, also known simply as diabetes, has been described as a chronic and
complex endocrine metabolic disorder that is a leading cause of death across the globe. It is …

Background: Lp (a)(lipoprotein [a]) levels are higher in individuals of African ancestry (AA)
than in individuals of European ancestry (EA). We examined associations of genetically …

Purpose Our objective was to comprehensively evaluate the risk of a broad range of birth
defects among offspring of women with diabetes, overall and stratified by pregestational …

Objective Pediatric patients have different diseases and outcomes than adults; however,
existing phecodes do not capture the distinctive pediatric spectrum of disease. We aim to …

Head and neck squamous cell carcinoma (HNSCC), which includes cancers of the oral
cavity and oropharynx, is a cause of substantial global morbidity and mortality. Strategies to …