Despite decades of research on cerebral malaria (CM) there is still a paucity of knowledge
about what actual causes CM and why certain people develop it. Although sequestration of …

Until recently, studies of natural killer (NK) cells in infection have focused almost entirely on
their role in viral infections. However, there is an increasing awareness of the potential for …

Background An understanding of the mechanisms mediating protective immunity against
malaria in humans is currently lacking, but critically important to advance the development of …

Cerebral malaria claims the lives of over 600,000 African children every year. To better
understand the pathogenesis of this devastating disease, we compared the cellular …

Severe falciparum malaria is a major cause of death in tropical countries, particularly in
African children. Rapid and accurate diagnosis and prognostic assessment are critical to …

Background In individuals living in malaria-endemic regions, parasitaemia thresholds for the
onset of clinical symptoms vary with transmission intensity. The mechanisms that mediate …

Abstract The interleukin-10 (IL-10) is generally considered as the most important cytokine
with anti-inflammatory properties and one of the key cytokines preventing inflammation …

Background Cerebral malaria (CM) is often fatal, and severe brain swelling is a predictor of
CM-related mortality. CM is characterized by elevated circulating pro-inflammatory cytokines …

Background Plasmodium falciparum malaria in India is characterized by high rates of severe
disease, with multiple organ dysfunction (MOD)—mainly associated with acute renal failure …

Rationale: Plasma-detectable biomarkers that rapidly and accurately diagnose bacterial
infections in children with suspected pneumonia could reduce the morbidity of respiratory …