Simple Summary The success of HPV as an infectious agent lies not within its ability to
cause disease, but rather in the adeptness of the virus to establish long-term persistent …

Infection with HPV starts with the access of the viral particles to basal cells in the epidermis,
potentially via microtraumas to the skin. The basal cells are able to keep away these …

Decades of research on the human papillomavirus oncogenes, E6 and E7, have given us
huge amounts of data on their expression, functions and structures. We know much about …

Human papillomaviruses (HPV) are the causative agents of cervical cancer and are also
associated with other genital malignancies, as well as an increasing number of head and …

Chromosome segregation during mitosis is highly regulated to ensure production of
genetically identical progeny. Recurrent mitotic errors cause chromosomal instability (CIN) …

Human papillomaviruses (HPV) activate a number of host factors to control their
differentiation-dependent life cycles. The transcription factor signal transducer and activator …

Cutaneous beta genus human papillomaviruses (β-HPVs) are suspected to promote the
development of nonmelanoma skin cancer (NMSC) by destabilizing the host genome …

The central importance of cell polarity control is emphasized by the frequency with which it is
targeted by many diverse viruses. It is clear that in targeting key polarity control proteins …

The high-risk α-type papillomaviruses have a C-terminal PDZ-binding motif (PBM) on one of
the two major oncoproteins E6 or E7; the vast majority on E6. The PBM is essential for the …

Upon infection, human papillomavirus (HPV) manipulates host cell gene expression to
create an environment that is supportive of a productive and persistent infection. The virus …