Anti-obesity drug discovery: advances and challenges

TD Müller, M Blüher, MH Tschöp… - Nature Reviews Drug …, 2022 - nature.com
Enormous progress has been made in the last half-century in the management of diseases
closely integrated with excess body weight, such as hypertension, adult-onset diabetes and …

The genetics of obesity: from discovery to biology

RJF Loos, GSH Yeo - Nature Reviews Genetics, 2022 - nature.com
The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

Clinical practice guideline for the evaluation and treatment of children and adolescents with obesity

SE Hampl, SG Hassink, AC Skinner, SC Armstrong… - …, 2023 - publications.aap.org
You have in your hands, or at your fingertips, the first edition of the American Academy of
Pediatrics clinical practice guideline for evaluation and management of children and …

Animal models of obesity and diabetes mellitus

M Kleinert, C Clemmensen, SM Hofmann… - Nature Reviews …, 2018 - nature.com
More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

European guidelines for obesity management in adults

V Yumuk, C Tsigos, M Fried, K Schindler, L Busetto… - Obesity facts, 2015 - karger.com
Obesity is a chronic metabolic disease characterised by an increase of body fat stores. It is a
gateway to ill health, and it has become one of the leading causes of disability and death …

AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity

MS Vohra, K Benchoula, CJ Serpell, WE Hwa - European journal of …, 2022 - Elsevier
Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

Overweight and obesity: prevalence, consequences, and causes of a growing public health problem

EP Williams, M Mesidor, K Winters, PM Dubbert… - Current obesity …, 2015 - Springer
This review considers a variety of perspectives on overweight and obesity (OW/obesity),
including measurement and classification; prevalence and changes in prevalence in recent …

Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms

JE Hall, JM do Carmo, AA da Silva, Z Wang… - Circulation …, 2015 - Am Heart Assoc
Excess weight gain, especially when associated with increased visceral adiposity, is a major
cause of hypertension, accounting for 65% to 75% of the risk for human primary (essential) …

Genetics of obesity: what we have learned over decades of research

C Bouchard - Obesity, 2021 - Wiley Online Library
There is a genetic component to human obesity that accounts for 40% to 50% of the
variability in body weight status but that is lower among normal weight individuals (about …

[PDF][PDF] Overweight and obesity in children and adolescents

NK Güngör - Journal of clinical research in pediatric …, 2014 - jag.journalagent.com
Obesity among children, adolescents and adults has emerged as one of the most serious
public health concerns in the 21st century. The worldwide prevalence of childhood obesity …