LPA receptor signaling: pharmacology, physiology, and pathophysiology
Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …
nonvertebrate organisms that mediates diverse biological actions and demonstrates …
The emerging role of lysophosphatidic acid in cancer
GB Mills, WH Moolenaar - Nature Reviews Cancer, 2003 - nature.com
The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation,
migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA …
migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA …
The Concise Guide to PHARMACOLOGY 2013/14: G protein‐coupled receptors
SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
Lysophospholipid receptors: signaling and biology
▪ Abstract Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …
International union of basic and clinical pharmacology. LXXVIII. Lysophospholipid receptor nomenclature
Lysophospholipids are cell membrane-derived lipids that include both glycerophospholipids
such as lysophosphatidic acid (LPA) and sphingoid lipids such as sphingosine 1-phosphate …
such as lysophosphatidic acid (LPA) and sphingoid lipids such as sphingosine 1-phosphate …
[HTML][HTML] Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism
DM Zu Heringdorf, KH Jakobs - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
The lysophospholipids, sphingosine-1-phosphate (S1P), lysophosphatidic acid (LPA),
sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse …
sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse …
Lysophospholipid G protein-coupled receptors
B Anliker, J Chun - Journal of Biological Chemistry, 2004 - ASBMB
The many biological responses documented for lysophospholipids that include
lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to …
lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to …
Lysophosphatidic acid signaling in cancer cells: what makes LPA so special?
Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …
Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo
H Zhang, X Xu, J Gajewiak, R Tsukahara, Y Fujiwara… - Cancer research, 2009 - AACR
Signal transduction modifiers that modulate the lysophosphatidic acid (LPA) pathway have
potential as anticancer agents. Herein, we describe metabolically stabilized LPA analogues …
potential as anticancer agents. Herein, we describe metabolically stabilized LPA analogues …
Molecular mechanisms of lysophosphatidic acid action
G Tigyi, AL Parrill - Progress in lipid research, 2003 - Elsevier
Lysophosphatidic acid (radyl-glycerol-phosphate, LPA) has captured the interest of lipid
biochemists, cell biologists, physiologists, and physicians alike due to its myriad biological …
biochemists, cell biologists, physiologists, and physicians alike due to its myriad biological …