Short telomeres confer risk of degenerative diseases. Chronic psychological stress can lead
to disease through many pathways, and research from in vitro studies to human longitudinal …

Biological aging involves an interplay of conserved and targetable molecular mechanisms,
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …

Aging is a natural process, which plays a critical role in the pathogenesis of a variety of
diseases, ie, aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease …

The finding that transcription occurs at chromosome ends has opened new fields of study on
the roles of telomeric transcripts in chromosome end maintenance and genome stability …

Abstract Alternative Lengthening of Telomeres (ALT) is a Break-Induced Replication (BIR)-
based mechanism elongating telomeres in a subset of human cancer cells. While the notion …

Aging is a fundamental biological process accompanied by a general decline in tissue
function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive …

Aging is a risk factor for several pathologies, restricting one's health span, and promoting
chronic diseases (eg, cardiovascular and neurodegenerative diseases), as well as cancer …

The natural aging process is carried out by a progressive loss of homeostasis leading to a
functional decline in cells and tissues. The accumulation of these changes stem from a …

Stress exposure can leave long-term footprints within the organism, like in telomeres (TLs),
protective chromosome caps that shorten during cell replication and following exposure to …

The telomeric long noncoding RNA TERRA has been implicated in regulating telomere
maintenance by telomerase and homologous recombination, and in influencing telomeric …