Elastin-like polypeptides for biomedical applications

AK Varanko, JC Su, A Chilkoti - Annual review of biomedical …, 2020 - annualreviews.org
Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human
elastin. Their unique properties—including lower critical solution temperature phase …

Mechanisms of drug release in nanotherapeutic delivery systems

PT Wong, SK Choi - Chemical reviews, 2015 - ACS Publications
Targeted drug delivery refers to an established therapeutic strategy that develops platforms
and nanoscale devices for selective delivery of small drug molecules and therapeutic genes …

Protein-based nanocarriers as promising drug and gene delivery systems

AO Elzoghby, WM Samy, NA Elgindy - Journal of controlled release, 2012 - Elsevier
Among the available potential colloidal drug carrier systems, protein-based nanocarriers are
particularly interesting. Meeting requirements such as low cytotoxicity, abundant renewable …

Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection

J Andrew MacKay, M Chen, JR McDaniel, W Liu… - Nature materials, 2009 - nature.com
New strategies to self-assemble biocompatible materials into nanoscale, drug-loaded
packages with improved therapeutic efficacy are needed for nanomedicine. To address this …

Elastin‐like polypeptides: biomedical applications of tunable biopolymers

SR MacEwan, A Chilkoti - Peptide Science: Original Research …, 2010 - Wiley Online Library
Artificial repetitive polypeptides have grown in popularity as a bioinspired alternative to
synthetic polymers. The genetically encoded synthesis, monodispersity, potential lack of …

Applications of elastin-like polypeptides in drug delivery

SR MacEwan, A Chilkoti - Journal of Controlled Release, 2014 - Elsevier
Elastin-like polypeptides (ELPs) are biopolymers inspired by human elastin. Their lower
critical solution temperature phase transition behavior and biocompatibility make them …

A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models

J Bhattacharyya, JJ Bellucci, I Weitzhandler… - Nature …, 2015 - nature.com
Packaging clinically relevant hydrophobic drugs into a self-assembled nanoparticle can
improve their aqueous solubility, plasma half-life, tumour-specific uptake and therapeutic …

Protein–polymer conjugation—moving beyond PEGylation

Y Qi, A Chilkoti - Current opinion in chemical biology, 2015 - Elsevier
Highlights•Limitations of conjugating poly (ethylene glycol) to proteins and peptides have
become increasingly apparent.•Various polymers have shown promise as PEG …

Peptide-based biopolymers in biomedicine and biotechnology

D Chow, ML Nunalee, DW Lim, AJ Simnick… - Materials Science and …, 2008 - Elsevier
Peptides are emerging as a new class of biomaterials due to their unique chemical,
physical, and biological properties. The development of peptide-based biomaterials is …

Genetically Engineered Viral Vectors and Organic‐Based Non‐Viral Nanocarriers for Drug Delivery Applications

S Hajebi, S Yousefiasl, I Rahimmanesh… - Advanced …, 2022 - Wiley Online Library
Conventional drug delivery systems are challenged by concerns related to systemic toxicity,
repetitive doses, drug concentrations fluctuation, and adverse effects. Various drug delivery …