Chronic and recurrent infections occur commonly in both type 1 and type 2 diabetes (T1D,
T2D) and increase patient morbidity and mortality. Neutrophils are professional phagocytes …

Cystic fibrosis (CF) is a common, life-threatening, multisystemic, autosomal recessive
disorder. In the last few years, giant steps have been made with regard to the understanding …

Neutrophils have a prominent role in all human immune responses against any type of
pathogen or stimulus. The lungs are a major neutrophil reservoir and neutrophilic …

Genetic defects in cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene
cause CF. Infants with CFTR mutations show a peribronchial neutrophil infiltration prior to …

Persistent neutrophil-dominated lung inflammation contributes to lung damage in cystic
fibrosis (CF). However, the mechanisms that drive persistent lung neutrophilia and tissue …

Introduction Cystic fibrosis (CF) is a life-threatening inherited disease caused by mutations
in the gene encoding the CF transmembrane conductance regulator (CFTR) protein, an …

Mucus plugging constitutes a nutrient‐rich nidus for a bacterial infection that has long been
recognized as a potent stimulus for neutrophilic airway inflammation driving progressive …

Rationale: Cystic fibrosis (CF) is a life-shortening, multisystem hereditary disease caused by
abnormal chloride transport. CF lung disease is driven by innate immune dysfunction and …

Neutrophils are key cells of the innate immune system. It is now understood that this
leukocyte population is diverse in both the basal composition and functional plasticity …

Cystic fibrosis (CF) is one of the most common life-limiting recessive genetic disorders in
Caucasians, caused by mutations in the cystic fibrosis transmembrane conductance …