Early-onset preeclampsia has been linked to poor placentation and fetal growth restriction,
whereas late-onset preeclampsia was suggested to result from maternal factors. We have …

Abnormal placentation is considered as an underlying cause of various pregnancy
complications such as miscarriage, preeclampsia and intrauterine growth restriction, the …

Physiological transformation with remodeling of the uteroplacental spiral arteries is key to a
successful placentation and normal placental function. It is an intricate process that involves …

During placentation invasive extravillous trophoblasts (EVTs) migrate into the maternal
uterus and modify its vessels. In particular, remodeling of the spiral arteries by EVTs is …

Macrophages perform many specific functions including host defense, homeostasis,
angiogenesis, and tissue development. Macrophages are the second most abundant …

Wingless ligands, a family of secreted proteins, are critically involved in organ development
and tissue homeostasis by ensuring balanced rates of stem cell proliferation, cell death and …

Correct development of the human placenta and its differentiated epithelial cells, syncytial
trophoblasts (STBs) and extravillous trophoblasts (EVTs), is crucial for a successful …

Tissue macrophages play an important role in all stages of pregnancy, including uterine
stromal remodeling (decidualization) before embryo implantation, parturition, and post …

BACKGROUND Pre-eclampsia, small-for-gestational-age infants, preterm birth and
recurrent miscarriage complicate a significant number of pregnancies. The vascular …

BACKGROUND During pregnancy, maternal uterine spiral arteries (SAs) are remodelled
from minimal-flow, high-resistance vessels into larger diameter vessels with low resistance …