Abstract Changes in DNA methylation profiles are common features of development and in a
number of human diseases, such as cancer and imprinting disorders like Beckwith …

Genomic imprinting is a form of epigenetic inheritance whereby the regulation of a gene or
chromosomal region is dependent on the sex of the transmitting parent. During …

Igf2 and H19 exhibit parent-of-origin-specific monoallelic expression. H19 is expressed from
the maternal chromosome and Igf2 from the paternal. The two genes share enhancer …

H19 and Igf2 are expressed in a monoallelic fashion from the maternal and paternal
chromosomes, respectively. A region upstream of H19 has been shown to regulate such …

Genomic imprinting, whereby certain genes are expressed dependent on whether they are
maternally or paternally inherited, is restricted to mammals and angiosperm plants. This …

Deregulation of imprinted genes has been observed in a number of human diseases such
as Beckwith–Wiedemann syndrome, Prader–Willi/Angelman syndromes and cancer …

Methylation of CpG dinucleotides is correlated with transcriptional repression of genes,
including imprinted genes. In the case of the imprinted H19 gene, a 2 kb imprinting control …

The closely linked H19 and Igf2 genes show highly similar patterns of gene expression but
are reciprocally imprinted. H19 is expressed almost exclusively from the maternally inherited …

Imprinted genes, such as the closely linked genes H19 and Igf2, are expressed from either
the maternal or the paternal chromosome, but not both. A newly discovered mechanism for …

The imprinted Igf2 gene is associated with a small upstream region that is differentially
methylated on the active paternal allele. We have identified a repressor element within this …