Nucleic acid therapy can achieve lasting and even curative effects through gene
augmentation, gene suppression, and genome editing. However, it is difficult for naked …

With the growing demand for clinically reliable therapeutics, traditional small molecule drugs
are increasingly limited by their short circulation duration, low bioavailability, and poor …

Proteins have tremendous potential for vaccine development and disease treatment, but
multiple extracellular and intracellular biological barriers must be overcome before they can …

Polymers used for the delivery of nucleic acids (NAs) typically possess ionizable, cationic
moieties enabling their electrostatic interactions with negatively charged NAs and form …

Antiapoptotic Bcl‐2 protein's upregulated expression is a key reason for drug resistance
leading to failure of chemotherapy. In this report, a series of biocompatible amphiphilic …

Peptide dendrimers, due to their biocompatibility and low toxicity, are highly promising
candidates as nanocarriers for drugs and genes. The development of this kind of delivery …

Gene therapy has emerged as a promising tool for treating different intractable diseases,
particularly cancer or even viral diseases such as COVID‐19 (coronavirus disease 2019). In …

Polyethylenimines (PEIs) are being explored as efficient non-viral nanocarriers for nucleic
acid delivery in vitro and in vivo. To address limitations regarding PEI efficacy and …

The delivery of small interfering RNAs (siRNA) is an efficient method for gene silencing
through the induction of RNA interference (RNAi). It critically relies, however, on efficient …

Carbohydrates, one of the most abundant natural compounds and key participants in many
biological processes, are relevant in medical and industrial fields. In comparison with …