Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …
dependent dementia. There is currently no effective treatment for AD, which may be …
The essential elements of Alzheimer's disease
Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …
Critical review of exposure and effects: implications for setting regulatory health criteria for ingested copper
AA Taylor, JS Tsuji, MR Garry, ME McArdle… - Environmental …, 2020 - Springer
Decades of study indicate that copper oral exposures are typically not a human health
concern. Ingesting high levels of soluble copper salts can cause acute gastrointestinal …
concern. Ingesting high levels of soluble copper salts can cause acute gastrointestinal …
Metal toxicity links to Alzheimer's disease and neuroinflammation
As the median age of the population increases, the number of individuals with Alzheimer's
disease (AD) and the associated socio-economic burden are predicted to worsen. While …
disease (AD) and the associated socio-economic burden are predicted to worsen. While …
[HTML][HTML] Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer's disease: Limitations, and current and future perspectives
Background Alzheimer's disease (AD) is the most prevalent cause of cognitive impairment
and dementia worldwide. The pathobiology of the disease has been studied in the form of …
and dementia worldwide. The pathobiology of the disease has been studied in the form of …
Bioinorganic chemistry of Alzheimer's disease
KP Kepp - Chemical reviews, 2012 - ACS Publications
Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …
of all cases), associated with loss of memory (in particular episodic memory), cognitive …
Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease
Q Li, S He, Y Chen, F Feng, W Qu, H Sun - European journal of medicinal …, 2018 - Elsevier
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders in elderly
people. Considering the multifactorial nature of AD, the concept of multi-target-directed …
people. Considering the multifactorial nature of AD, the concept of multi-target-directed …
Effects of in vivo conditions on amyloid aggregation
One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …
govern protein misfolding and aggregation, which is a highly complex process that is …
Untangling amyloid-β, tau, and metals in Alzheimer's disease
Protein misfolding and metal ion dyshomeostasis are believed to underlie numerous
neurodegenerative diseases, including Alzheimer's disease (AD). The pathological hallmark …
neurodegenerative diseases, including Alzheimer's disease (AD). The pathological hallmark …
Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation
M Jazvinšćak Jembrek, PR Hof… - Oxidative medicine and …, 2015 - Wiley Online Library
Alzheimer's disease (AD), the most common chronic and progressive neurodegenerative
disorder, is characterized by extracellular deposits of amyloid β‐peptides (Aβ) and …
disorder, is characterized by extracellular deposits of amyloid β‐peptides (Aβ) and …