The natural history of cervical HPV infection: unresolved issues

CBJ Woodman, SI Collins, LS Young - Nature Reviews Cancer, 2007 - nature.com
The identification of high-risk human papillomavirus (HPV) types as a necessary cause of
cervical cancer offers the prospect of effective primary prevention and the possibility of …

Susceptibility to cervical cancer: an overview

AC de Freitas, APAD Gurgel, BS Chagas… - Gynecologic …, 2012 - Elsevier
Cervical cancer is the second most common cancer in females worldwide. It is well-
established that Human Papillomavirus (HPV) infections play a critical role in the …

Bridging links between long noncoding RNA HOTAIR and HPV oncoprotein E7 in cervical cancer pathogenesis

S Sharma, P Mandal, T Sadhukhan… - Scientific reports, 2015 - nature.com
Human Papillomavirus (HPV) type 16 oncoprotein E7 plays a major role in cervical
carcinogenesis by interacting with and functionally inactivating various host regulatory …

Differential methylation of E2 binding sites in episomal and integrated HPV 16 genomes in preinvasive and invasive cervical lesions

A Chaiwongkot, S Vinokurova… - … journal of cancer, 2013 - Wiley Online Library
Enhanced expression of the HPV 16 E6‐E7 oncogenes may trigger neoplastic
transformation of the squamous epithelial cells at the uterine cervix. The HPV E2 protein is a …

Niche adaptation and viral transmission of human papillomaviruses from archaic hominins to modern humans

Z Chen, R DeSalle, M Schiffman, R Herrero… - PLoS …, 2018 - journals.plos.org
Recent discoveries on the origins of modern humans from multiple archaic hominin
populations and the diversity of human papillomaviruses (HPVs) suggest a complex …

[HTML][HTML] CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2

B Bhattacharjee, S Sengupta - Virology, 2006 - Elsevier
Human papillomavirus type 16 (HPV-16) E2 protein negatively regulates transcription of the
E6 and E7 genes. This study was done to test the hypothesis that methylation of the HPV 16 …

A meta-analysis of human papillomavirus type-distribution in women from South Asia: implications for vaccination

N Bhatla, N Lal, YP Bao, T Ng, YL Qiao - Vaccine, 2008 - Elsevier
OBJECTIVE: To determine human papillomavirus (HPV) prevalence and type-distribution in
women from South Asia, with and without cervical lesions, in order to estimate the impact of …

Physical state & copy number of high risk human papillomavirus type 16 DNA in progression of cervical cancer

S Shukla, S Mahata, G Shishodia… - Indian Journal of …, 2014 - journals.lww.com
Methods: Both, viral load and integration status of HPV16 were determined by real time URR
PCR and estimation of E2: E6 ratio in a total of 130 PGMY-RLB-confirmed, monotypic …

Genetic and epigenetic changes of HPV16 in cervical cancer differentially regulate E6/E7 expression and associate with disease progression

D Mazumder, RK Singh, S Mitra, S Dutta… - Gynecologic …, 2011 - Elsevier
OBJECTIVE: The study was aimed at understanding the complex interactions of genetic and
epigenetic events in expression of HPV16 E6/E7 and progression of cervical carcinoma. For …

Identification of genetic variation in the lncRNA HOTAIR associated with HPV16-related cervical cancer pathogenesis

S Sharma Saha, R Roy Chowdhury, NR Mondal… - Cellular oncology, 2016 - Springer
Purpose Previously, over-expression of the long noncoding RNA (lncRNA) HOTAIR has
been found to be associated with the invasive and metastatic capacities of several epithelial …