Alzheimer's disease and β-secretase inhibition: an update with a focus on computer-aided inhibitor design
Introduction: Alzheimer's disease (AD) is an intensifying neurodegenerative illness due to its
irreversible nature. Identification of β128; site Amyloid Precursor Protein (APP) cleaving en …
irreversible nature. Identification of β128; site Amyloid Precursor Protein (APP) cleaving en …
Targeting Alzheimer's disease with multimodal polypeptide-based nanoconjugates
A Duro-Castano, C Borrás, V Herranz-Pérez… - Science …, 2021 - science.org
Alzheimer's disease (AD), the most prevalent form of dementia, remains incurable mainly
due to our failings in the search for effective pharmacological strategies. Here, we describe …
due to our failings in the search for effective pharmacological strategies. Here, we describe …
Potential of medicinal plants as neuroprotective and therapeutic properties against amyloid-β-related toxicity, and glutamate-induced excitotoxicity in human neural …
Alzheimer's disease (AD) and Parkinson's disease (PD) are notorious neurodegenerative
diseases amongst the general population. Being age-associated diseases, the prevalence …
diseases amongst the general population. Being age-associated diseases, the prevalence …
Identification of potential neuroprotective compound from Ganoderma lucidum extract targeting microtubule affinity regulation kinase 4 involved in Alzheimer's …
Objective Alzheimer's disease (AD) is one of the most prevalent neurological ailments,
affecting around 50 million individuals globally. The condition is characterized by nerve cell …
affecting around 50 million individuals globally. The condition is characterized by nerve cell …
Computational modelling of potent β-secretase (BACE1) inhibitors towards Alzheimer's disease treatment
Researchers have identified the β-amyloid precursor protein cleaving enzyme 1 (BACE1) in
the multifactorial pathway of Alzheimer's disease (AD) as a drug target. The design and …
the multifactorial pathway of Alzheimer's disease (AD) as a drug target. The design and …
Chemical composition and biological properties of Synedrella nodiflora (L.) Gaertn: A comparative investigation of different extraction methods
D Zheleva-Dimitrova, KI Sinan, OK Etienne… - Process …, 2020 - Elsevier
Abstract Synedrella nodiflora (L.) Gaertn.(Asteraceae), is a weed with ethnomedicinal uses.
To extend scientific information on this species, we evaluated the effects of different …
To extend scientific information on this species, we evaluated the effects of different …