Nociception in fruit fly larvae

JC Boivin, J Zhu, T Ohyama - Frontiers in Pain Research, 2023 - frontiersin.org
Nociception, the process of encoding and processing noxious or painful stimuli, allows
animals to detect and avoid or escape from potentially life-threatening stimuli. Here, we …

Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization in Drosophila

NJ Himmel, A Sakurai, AA Patel, S Bhattacharjee… - Elife, 2023 - elifesciences.org
Individual sensory neurons can be tuned to many stimuli, each driving unique, stimulus-
relevant behaviors, and the ability of multimodal nociceptor neurons to discriminate between …

[HTML][HTML] Alcohol-free synthesis, biological assessment, in vivo toxicological evaluation, and in silico analysis of novel silane quaternary ammonium compounds …

G Tagorti, B Yalçın, M Güneş, AY Burgazlı… - Journal of Hazardous …, 2024 - Elsevier
Quaternary ammonium compounds (QACs) are commonly used as disinfectants for
industrial, medical, and residential applications. However, adverse health outcomes have …

Transient and Steady-State Properties of Drosophila Sensory Neurons Coding Noxious Cold Temperature

N Maksymchuk, A Sakurai, DN Cox… - Frontiers in Cellular …, 2022 - frontiersin.org
Coding noxious cold signals, such as the magnitude and rate of temperature change, play
essential roles in the survival of organisms. We combined electrophysiological and …

Evolution of transient receptor potential (TRP) ion channels in Antarctic fishes (Cryonotothenioidea) and identification of putative thermosensors

JM York, HH Zakon - Genome Biology and Evolution, 2022 - academic.oup.com
Animals rely on their sensory systems to inform them of ecologically relevant environmental
variation. In the Southern Ocean, the thermal environment has remained between− 1.9 and …

Modality specific roles for metabotropic GABAergic signaling and calcium induced calcium release mechanisms in regulating cold nociception

AA Patel, A Sakurai, NJ Himmel… - Frontiers in molecular …, 2022 - frontiersin.org
Calcium (Ca2+) plays a pivotal role in modulating neuronal-mediated responses to modality-
specific sensory stimuli. Recent studies in Drosophila reveal class III (CIII) multidendritic …

Cold-Temperature Coding with Bursting and Spiking Based on TRP Channel Dynamics in Drosophila Larva Sensory Neurons

N Maksymchuk, A Sakurai, DN Cox… - International Journal of …, 2023 - mdpi.com
Temperature sensation involves thermosensitive TRP (thermoTRP) and non-TRP channels.
Drosophila larval Class III (CIII) neurons serve as the primary cold nociceptors and express …

Transient receptor potential (TRP) channels in Sebastes schlegelii: Genome-wide identification and ThermoTRP expression analysis under high-temperature

J Huang, X Wang, X Guo, Q Liu, J Li - Gene, 2024 - Elsevier
Abstract Transient Receptor Potential (TRP) channels, essential for sensing environmental
stimuli, are widely distributed. Among them, thermosensory TRP channels play a crucial role …

[HTML][HTML] Protocols for measuring cold-evoked neural activity and cold tolerance in Drosophila larvae following fictive cold acclimation

NJ Himmel, A Sakurai, KJ Donaldson, DN Cox - STAR protocols, 2022 - Elsevier
Here, we outline protocols to study cold acclimation in Drosophila from a neurobiological
perspective, starting with fictive cold acclimation using a custom-built optogenetics-housing …

Chloride-dependent mechanisms of multimodal sensory discrimination and neuropathic sensitization in Drosophila

NJ Himmel, A Sakurai, JM Letcher, AA Patel… - bioRxiv, 2021 - biorxiv.org
Individual sensory neurons can be tuned to many stimuli, each driving unique, stimulus-
relevant behaviors, and the ability of multimodal nociceptor neurons to discriminate between …