Although iron is essential for living organisms to survive, its reactive properties require strict
regulation in order to prevent toxic effects. Hepcidin, a liver produced peptide hormone, is …

Patients with alcoholic liver disease frequently exhibit increased body iron stores, as
reflected by elevated serum iron indices (transferrin saturation, ferritin) and hepatic iron …

Although hepcidin expression was shown to be induced by the BMP/Smad signaling
pathway, it is not yet known how iron regulates this pathway and what its exact molecular …

Patients with alcoholic liver disease frequently exhibit iron overload in association with
increased hepatic fibrosis. Even moderate alcohol consumption elevates body iron stores; …

ZIP14 (slc39A14) is a zinc transporter induced in response to pro-inflammatory stimuli.
ZIP14 induction accompanies the reduction in serum zinc (hypozincemia) of acute …

Hepcidin is a central regulator of iron homeostasis. HFE and transferrin receptor 2 (TFR2)
are mutated in adult‐onset forms of hereditary hemochromatosis and regulate the …

Hepcidin, a key regulator of iron metabolism, is synthesized by the liver. Hepcidin binds to
the iron exporter ferroportin to regulate the release of iron into plasma from macrophages …

Inappropriately low expression of the key iron regulator hepcidin (HAMP) causes iron
overload in untransfused patients affected by β-thalassemia intermedia and Hamp …

Anemia is a common complication of infections and inflammatory diseases, but the few
mouse models of this condition are not well characterized. We analyzed in detail the …

Abstract Iron regulatory protein 2 (IRP2)-deficient mice have been reported to suffer from late-
onset neurodegeneration by an unknown mechanism. We report that young adult Irp2-/-mice …