Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

The Oct4 protein, encoded by the Pou5f1 gene was the very first master gene, discovered 25
years ago, to be absolutely required for the stemness properties of murine and primate …

Evidence has revealed that transcription factors play essential roles in regulation of multiple
cellular processes, including cell proliferation, metastasis, EMT, cancer stem cells and …

Recently, evidences show that cancer stem cells (CSCs) are a type of cancer cell group with
self-renewal and play a huge role in tumor recurrence, metastasis, and drug resistance …

Nanog is a master pluripotency factor of embryonic stem cells (ESCs). Stable expression of
Nanog is essential to maintain the stemness of ESCs. However, Nanog is a short-lived …

Recurrence and drug resistance of breast cancer are still the main reasons for breast cancer-
associated deaths. Cancer stem cell (CSC) model has been proposed as a hypothesis for …

Itch or itchy E3 ubiquitin ligase was initially discovered by genetic studies on the mouse coat
color changes, and its deletion results in an itchy phenotype with constant skin scratching …

Somatic cells may be reprogrammed to pluripotent state by ectopic expression of certain
transcription factors; namely, OCT4, SOX2, KLF4 and c-MYC. However, the molecular and …

Fsh-mediated regulation of zebrafish spermatogenesis includes modulating the expression
of testicular growth factors. Here, we study if and how two Sertoli cell-derived Fsh …

Octamer-binding transcription factor 3/4 (OCT-3/4), which is involved in the tumorigenesis of
somatic cancers, has diverse functions during cancer development. Overexpression of OCT …