Transposable elements (TEs) are insertional mutagens that contribute greatly to the
plasticity of eukaryotic genomes, influencing the evolution and adaptation of species as well …

Only a small proportion of patients with cancer show lasting responses to immune
checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an …

Neurodegenerative diseases (NDs), including the most prevalent Alzheimer's disease and
Parkinson disease, share common pathological features. Despite decades of gene‐centric …

All life forms defend their genome against DNA invasion. Eukaryotic cells recognize
incoming DNA and limit its transcription through repressive chromatin modifications. The …

Decrypting the rearrangements that drive mammalian chromosome evolution is critical to
understanding the molecular bases of speciation, adaptation, and disease susceptibility …

The microbiota plays a fundamental role in regulating host immunity. However, the
processes involved in the initiation and regulation of immunity to the microbiota remain …

Reprogramming of H3K9me3-dependent heterochromatin is required for early development.
How H3K9me3 is involved in early human development remains, however, largely unclear …

In eukaryotes, repetitive DNA sequences are transcriptionally silenced through histone H3
lysine 9 trimethylation (H3K9me3). Loss of silencing of the repeat elements leads to genome …

Mice harbor∼ 2800 intact copies of the retrotransposon Long Interspersed Element 1 (L1).
The in vivo retrotransposition capacity of an L1 copy is defined by both its sequence integrity …

The molecular basis underlying the interaction between retrotransposable elements (RTEs)
and the human genome remains poorly understood. Here, we profiled N 6-methyladenosine …