Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …

For almost 50 years, ebolaviruses and related filoviruses have been repeatedly reemerging
across the vast equatorial belt of the African continent to cause epidemics of highly fatal …

Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens
that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in …

Background Ebolavirus species Zaire (ZEBOV) causes highly lethal hemorrhagic fever,
resulting in the death of 90% of patients within days. Most information on immune responses …

Ebola and Marburg viruses are filoviruses: filamentous, enveloped viruses that cause
haemorrhagic fever. Filoviruses are within the order Mononegavirales, which also includes …

Vertebrate genomes contain numerous copies of retroviral sequences, acquired over the
course of evolution. Until recently they were thought to be the only type of RNA viruses to be …

The cytoplasmic pattern recognition receptor RIG-I is activated by viral RNA and induces
type I IFN responses to control viral replication. The cellular dsRNA binding protein PACT …

Recently emerged viral infectious diseases (VIDs) include HIV/AIDS, influenzas H5N1 and
2009 H1N1, SARS, and Ebola hemorrhagic fevers. Earlier research determined metabolic …

During viral RNA synthesis, Ebola virus (EBOV) nucleoprotein (NP) alternates between an
RNA-template-bound form and a template-free form to provide the viral polymerase access …

ABSTRACT The Ebola virus (EBOV) VP35 protein antagonizes the early antiviral alpha/beta
interferon (IFN-α/β) response. We previously demonstrated that VP35 inhibits the virus …