Neurodevelopmental outcomes of prenatal preeclampsia exposure

SB Gumusoglu, ASS Chilukuri, DA Santillan… - Trends in …, 2020 - cell.com
Preeclampsia is a dangerous hypertensive disorder of pregnancy with known links to
negative child health outcomes. Here, we review epidemiological and basic neuroscience …

Lasting effects of intrauterine exposure to preeclampsia on offspring and the underlying mechanism

HQ Lu, R Hu - American journal of perinatology reports, 2019 - thieme-connect.com
Preeclampsia is a common pregnancy complication which can have adverse impact on both
mother and baby. In addition to the short term effects, a large body of epidemiological …

[HTML][HTML] Distinct placental molecular processes associated with early-onset and late-onset preeclampsia

Z Ren, Y Gao, Y Gao, G Liang, Q Chen, S Jiang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Patients with preeclampsia display a spectrum of onset time and severity of
clinical presentation, yet the underlying molecular bases for the early-onset and late-onset …

Outer dense fibers stabilize the axoneme to maintain sperm motility

W Zhao, Z Li, P Ping, G Wang… - Journal of cellular and …, 2018 - Wiley Online Library
Outer dense fibers (ODFs), as unique accessory structures in mammalian sperm, are
considered to play a role in the protection of the sperm tail against shear forces. However …

Brain structural and vascular anatomy is altered in offspring of pre-eclamptic pregnancies: a pilot study

MT Rätsep, A Paolozza, AF Hickman… - American Journal …, 2016 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Pre-eclampsia is a serious clinical gestational disorder
occurring in 3%–5% of all human pregnancies and characterized by endothelial dysfunction …

The L-NAME mouse model of preeclampsia and impact to long-term maternal cardiovascular health

N de Alwis, NK Binder, S Beard… - Life science …, 2022 - life-science-alliance.org
Preeclampsia affects∼ 2–8% of pregnancies worldwide. It is associated with increased long-
term maternal cardiovascular disease risk. This study assesses the effect of the …

[HTML][HTML] Placental dysfunction: the core mechanism for poor neurodevelopmental outcomes in the offspring of preeclampsia pregnancies

D Liu, Q Gao, Y Wang, T Xiong - Placenta, 2022 - Elsevier
Preeclampsia (PE) is a leading condition threatening pregnant women and their offspring.
The offspring of PE pregnancies have a high risk of poor neurodevelopmental outcomes and …

Preeclampsia, fetal growth restriction, and 24-month neurodevelopment in very preterm infants

J Check, C Shuster, J Hofheimer… - JAMA Network …, 2024 - jamanetwork.com
Importance Preeclampsia has direct influences on a developing fetus and may impact
postnatal health, and fetal growth restriction (FGR) is often seen co-occurring with …

Preeclampsia-associated lncRNA INHBA-AS1 regulates the proliferation, invasion, and migration of placental trophoblast cells

S Jiang, Q Chen, H Liu, Y Gao, X Yang, Z Ren… - … Therapy-Nucleic Acids, 2020 - cell.com
Preeclampsia is believed to be caused by impaired placentation with insufficient trophoblast
invasion, leading to impaired uterine spiral artery remodeling and angiogenesis. However …

Altered offspring neurodevelopment in an L-NAME-induced preeclampsia rat model

N Nakamura, T Ushida, A Onoda, K Ueda… - Frontiers in …, 2023 - frontiersin.org
Introduction To investigate the mechanism underlying the increased risk of subsequent
neurodevelopmental disorders in children born to mothers with preeclampsia, we evaluated …