Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …

Ghrelin, a gastric-derived acylated peptide, regulates energy homeostasis by transmitting
information about peripheral nutritional status to the brain, and is essential for protecting …

Acyl-ghrelin administration increases food intake, body weight, and blood glucose. In
contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening …

Ghrelin administration induces food intake and body weight gain. Based on these actions,
the ghrelin system was initially proposed as an antiobesity target. Subsequent studies using …

Objective The hormone liver-expressed antimicrobial peptide-2 (LEAP2) is a recently
identified antagonist and an inverse agonist of the growth hormone secretagogue receptor …

Cold exposure triggers neogenesis in classic interscapular brown adipose tissue (iBAT) that
involves activation of β1-adrenergic receptors, proliferation of PDGFRA+ adipose tissue …

Discovered as a peptide involved in releasing growth hormone, ghrelin was initially
characterized as the “hunger hormone.” However, emerging research indicates that ghrelin …

Much effort has been directed at studying the orexigenic actions of administered ghrelin and
the potential effects of the endogenous ghrelin system on food intake, food reward, body …

The vast majority of patients with advanced breast cancer present skeletal complications that
severely compromise their quality of life. Breast cancer cells are characterized by a strong …

Despite the growing popular interest in sleep and diet, many gaps exist in our scientific
understanding of the interaction between circadian rhythms and metabolism. In this Review …