Neurofilament proteins as biomarkers to monitor neurological diseases and the efficacy of therapies

A Yuan, RA Nixon - Frontiers in neuroscience, 2021 - frontiersin.org
Biomarkers of neurodegeneration and neuronal injury have the potential to improve
diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy …

Management of traumatic brain injury: from present to future

R Crupi, M Cordaro, S Cuzzocrea, D Impellizzeri - Antioxidants, 2020 - mdpi.com
TBI (traumatic brain injury) is a major cause of death among youth in industrialized societies.
Brain damage following traumatic injury is a result of direct and indirect mechanisms; …

From biomechanics to pathology: predicting axonal injury from patterns of strain after traumatic brain injury

CK Donat, M Yanez Lopez, M Sastre, N Baxan… - Brain, 2021 - academic.oup.com
The relationship between biomechanical forces and neuropathology is key to understanding
traumatic brain injury. White matter tracts are damaged by high shear forces during impact …

Blood-based traumatic brain injury biomarkers–Clinical utilities and regulatory pathways in the United States, Europe and Canada

KK Wang, JC Munoz Pareja, S Mondello… - Expert review of …, 2021 - Taylor & Francis
Introduction Traumatic brain injury (TBI) is a major global health issue, resulting in
debilitating consequences to families, communities, and health-care systems. Prior research …

Potential biomarkers in Experimental Animal models for traumatic brain Injury

UM Deshetty, P Periyasamy - Journal of clinical medicine, 2023 - mdpi.com
Traumatic brain injury (TBI) is a complex and multifaceted disorder that has become a
significant public health concern worldwide due to its contribution to mortality and morbidity …

Advances in neuroproteomics for neurotrauma: unraveling insights for personalized medicine and future prospects

F Kobeissy, M Goli, H Yadikar, Z Shakkour… - Frontiers in …, 2023 - frontiersin.org
Neuroproteomics, an emerging field at the intersection of neuroscience and proteomics, has
garnered significant attention in the context of neurotrauma research. Neuroproteomics …

Post-traumatic meningitis is a diagnostic challenging time: a systematic review focusing on clinical and pathological features

R La Russa, A Maiese, N Di Fazio, A Morano… - International journal of …, 2020 - mdpi.com
Post-traumatic meningitis is a dreadful condition that presents additional challenges, in
terms of both diagnosis and management, when compared with community-acquired cases …

Multi-center pre-clinical consortia to enhance translation of therapies and biomarkers for traumatic brain injury: operation brain trauma therapy and beyond

PM Kochanek, CE Dixon, S Mondello… - Frontiers in …, 2018 - frontiersin.org
Current approaches have failed to yield success in the translation of neuroprotective
therapies from the pre-clinical to the clinical arena for traumatic brain injury (TBI). Numerous …

Acute blood levels of neurofilament light indicate one-year white matter pathology and functional impairment in repetitive mild traumatic brain injured mice

F Moro, I Lisi, D Tolomeo, G Vegliante… - Journal of …, 2023 - liebertpub.com
Mild traumatic brain injury (mTBI) mostly causes transient symptoms, but repeated (r) mTBI
can lead to neurodegenerative processes. Diagnostic tools to evaluate the presence of …

Glibenclamide treatment in traumatic brain injury: operation brain trauma therapy

RM Jha, S Mondello, HM Bramlett, CE Dixon… - Journal of …, 2021 - liebertpub.com
Glibenclamide (GLY) is the sixth drug tested by the Operation Brain Trauma Therapy (OBTT)
consortium based on substantial pre-clinical evidence of benefit in traumatic brain injury …