Long non-coding RNAs and cancer: a new frontier of translational research?
Tiling array and novel sequencing technologies have made available the transcription
profile of the entire human genome. However, the extent of transcription and the function of …
profile of the entire human genome. However, the extent of transcription and the function of …
Long non-coding RNAs and complex human diseases
Long non-coding RNAs (lncRNAs) are a heterogeneous class of RNAs that are generally
defined as non-protein-coding transcripts longer than 200 nucleotides. Recently, an …
defined as non-protein-coding transcripts longer than 200 nucleotides. Recently, an …
lncRNAdb: a reference database for long noncoding RNAs
Large numbers of long RNAs with little or no protein-coding potential [long noncoding RNAs
(lncRNAs)] are being identified in eukaryotes. In parallel, increasing data describing the …
(lncRNAs)] are being identified in eukaryotes. In parallel, increasing data describing the …
17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease
S Massone, I Vassallo, G Fiorino, M Castelnuovo… - Neurobiology of …, 2011 - Elsevier
Alternative splicing is a central component of human brain complexity; nonetheless, its
regulatory mechanisms are still largely unclear. In this work, we describe a novel non-coding …
regulatory mechanisms are still largely unclear. In this work, we describe a novel non-coding …
An intronic ncRNA-dependent regulation of SORL1 expression affecting Aβ formation is upregulated in post-mortem Alzheimer's disease brain samples
E Ciarlo, S Massone, I Penna… - Disease models & …, 2013 - journals.biologists.com
Recent studies indicated that sortilin-related receptor 1 (SORL1) is a risk gene for late-onset
Alzheimer's disease (AD), although its role in the aetiology and/or progression of this …
Alzheimer's disease (AD), although its role in the aetiology and/or progression of this …
Molecular landscape of long noncoding RNAs in brain disorders
S Yang, KH Lim, SH Kim, JY Joo - Molecular psychiatry, 2021 - nature.com
According to current paradigms, various risk factors, such as genetic mutations, oxidative
stress, neural network dysfunction, and abnormal protein degradation, contribute to the …
stress, neural network dysfunction, and abnormal protein degradation, contribute to the …
Insights into lncRNAs in Alzheimer's disease mechanisms
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common dementia among the elderly. The pathophysiology of AD is characterized by two …
common dementia among the elderly. The pathophysiology of AD is characterized by two …
RNA polymerase III transcription control elements: themes and variations
Eukaryotic genomes are punctuated by a multitude of tiny genetic elements, that share the
property of being recognized and transcribed by the RNA polymerase (Pol) III machinery to …
property of being recognized and transcribed by the RNA polymerase (Pol) III machinery to …
[HTML][HTML] NDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid β secretion
S Massone, E Ciarlo, S Vella, M Nizzari, T Florio… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Neuroblastoma Differentiation Marker 29 (NDM29) is a RNA polymerase (pol) III-transcribed
non-coding (nc) RNA whose synthesis drives neuroblastoma (NB) cell differentiation to a …
non-coding (nc) RNA whose synthesis drives neuroblastoma (NB) cell differentiation to a …
Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis
Y Luo, X Lu, H Xie - BioMed research international, 2014 - Wiley Online Library
DNA methylation primarily occurs on CpG dinucleotides and plays an important role in
transcriptional regulations during tissue development and cell differentiation. Over 25% of …
transcriptional regulations during tissue development and cell differentiation. Over 25% of …