The SOFA score—development, utility and challenges of accurate assessment in clinical trials

S Lambden, PF Laterre, MM Levy, B Francois - Critical Care, 2019 - Springer
Abstract The Sequential Organ Failure Assessment or SOFA score was developed to assess
the acute morbidity of critical illness at a population level and has been widely validated as a …

Sepsis associated acute kidney injury

JT Poston, JL Koyner - Bmj, 2019 - bmj.com
Sepsis is defined as organ dysfunction resulting from the host's deleterious response to
infection. One of the most common organs affected is the kidneys, resulting in sepsis …

High-dimensional characterization of post-acute sequelae of COVID-19

Z Al-Aly, Y Xie, B Bowe - Nature, 2021 - nature.com
The acute clinical manifestations of COVID-19 have been well characterized,, but the post-
acute sequelae of this disease have not been comprehensively described. Here we use the …

[HTML][HTML] Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19

PA Szabo, P Dogra, JI Gray, SB Wells, TJ Connors… - Immunity, 2021 - cell.com
Immune response dynamics in coronavirus disease 2019 (COVID-19) and their severe
manifestations have largely been studied in circulation. Here, we examined the relationship …

Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients

T Langer, M Brioni, A Guzzardella, E Carlesso… - Critical Care, 2021 - Springer
Background Limited data are available on the use of prone position in intubated, invasively
ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study is to …

Efficacy and safety of Paxlovid in severe adult patients with SARS-Cov-2 infection: a multicenter randomized controlled study

J Liu, X Pan, S Zhang, M Li, K Ma, C Fan… - The Lancet Regional …, 2023 - thelancet.com
Summary Background Nirmatrelvir plus ritonavir (Paxlovid) reduced the risk of
hospitalization or death by 89% in high-risk, ambulatory adults with COVID-19. We aimed at …

Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19

S Shaefi, SK Brenner, S Gupta, BP O'Gara… - Intensive care …, 2021 - Springer
Purpose Limited data are available on venovenous extracorporeal membrane oxygenation
(ECMO) in patients with severe hypoxemic respiratory failure from coronavirus disease 2019 …

A prospective study of neurologic disorders in hospitalized patients with COVID-19 in New York City

JA Frontera, S Sabadia, R Lalchan, T Fang, B Flusty… - Neurology, 2021 - AAN Enterprises
Objective To determine the prevalence and associated mortality of well-defined neurologic
diagnoses among patients with coronavirus disease 2019 (COVID-19), we prospectively …

Corticosteroid therapy for critically ill patients with Middle East respiratory syndrome

YM Arabi, Y Mandourah, F Al-Hameed… - American journal of …, 2018 - atsjournals.org
Rationale: Corticosteroid therapy is commonly used among critically ill patients with Middle
East Respiratory Syndrome (MERS), but its impact on outcomes is uncertain. Analyses of …

The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?

R Moreno, A Rhodes, L Piquilloud, G Hernandez… - Critical care, 2023 - Springer
Abstract The Sequential Organ Failure Assessment (SOFA) score was developed more than
25 years ago to provide a simple method of assessing and monitoring organ dysfunction in …