EGFR signaling pathway as therapeutic target in human cancers
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies
Amplification of epidermal growth factor receptor (EGFR) and its active mutant EGFRvIII
occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in …
occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in …
Glioblastoma: pathology, molecular mechanisms and markers
K Aldape, G Zadeh, S Mansouri, G Reifenberger… - Acta …, 2015 - Springer
Recent advances in genomic technology have led to a better understanding of key
molecular alterations that underlie glioblastoma (GBM). The current WHO-based …
molecular alterations that underlie glioblastoma (GBM). The current WHO-based …
The ErbB/HER family of protein-tyrosine kinases and cancer
R Roskoski Jr - Pharmacological research, 2014 - Elsevier
The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …
Chemotherapeutic drugs and mitochondrial dysfunction: focus on doxorubicin, trastuzumab, and sunitinib
S Gorini, A De Angelis, L Berrino… - Oxidative medicine …, 2018 - Wiley Online Library
Many cancer therapies produce toxic side effects whose molecular mechanisms await full
elucidation. The most feared and studied side effect of chemotherapeutic drugs is …
elucidation. The most feared and studied side effect of chemotherapeutic drugs is …
The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer
JL Hsu, MC Hung - Cancer and Metastasis Reviews, 2016 - Springer
Breast cancer affects approximately 1 in 8 women, and it is estimated that over 246,660
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
Emerging insights into the molecular and cellular basis of glioblastoma
GP Dunn, ML Rinne, J Wykosky… - Genes & …, 2012 - genesdev.cshlp.org
Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive
multiplatform genomic characterization has provided a higher-resolution picture of the …
multiplatform genomic characterization has provided a higher-resolution picture of the …
Understanding resistance to EGFR inhibitors—impact on future treatment strategies
DL Wheeler, EF Dunn, PM Harari - Nature reviews Clinical oncology, 2010 - nature.com
EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis.
Following ligand binding, EGFR stimulates downstream cell signaling cascades that …
Following ligand binding, EGFR stimulates downstream cell signaling cascades that …
Protein localization in disease and therapy
The eukaryotic cell is organized into membrane-covered compartments that are
characterized by specific sets of proteins and biochemically distinct cellular processes. The …
characterized by specific sets of proteins and biochemically distinct cellular processes. The …
PCNA: a silent housekeeper or a potential therapeutic target?
SC Wang - Trends in pharmacological sciences, 2014 - cell.com
Proliferating cell nuclear antigen (PCNA) is known as a molecular marker for proliferation
given its role in replication. Three identical molecules of PCNA form a molecular sliding …
given its role in replication. Three identical molecules of PCNA form a molecular sliding …