Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and painful condition
seen in patients undergoing treatment with common agents such as vincristine, paclitaxel …

An apoptotic program leading to controlled cell dismantling implies perturbations of nuclear
dynamics, as well as changes affecting the organelle structure and distribution. In human …

Chemotherapy-induced peripheral neuropathy (CIPN) is a major, dose-limiting adverse
effect experienced by cancer patients. Advancements in mechanism-based risk mitigation …

Cisplatin (cisPt), among the best known components of multi-drug front-line therapies used
for the treatments of solid tumors, such as the childhood neuroblastoma, acts through DNA …

Glioblastoma (GBM) is the most common tumor of the central nervous system. Current
therapies, often associated with severe side effects, are inefficacious to contrast the GBM …

Imbalances in metal homeostasis have been implicated in the progression and drug
response of cancer cells. Understanding these changes will enable identification of new …

Malignant glioma are often fatal and pose a significant therapeutic challenge. Here we have
employed α-helical right handed coiled coils (RHCC) which self-assemble into tetrameric …

Amiloride derivatives are a class of new promising chemotherapeutic agents. A
representative member of this family is the sodium–hydrogen antiporter inhibitor HMA (5-(N …

Gliomas are the most frequent primary tumours of the nervous system, characterised by high
degree of malignancy, widespread invasion and high-rate proliferation. Cisplatin and …

Cisplatin (CisPt) is a widely used chemotherapeutic drug whose side effects include muscle
weakness and cachexia. Here we analysed CisPt‐induced atrophy in C2C12 myotubes by a …