What determines large-scale anatomy? DNA does not directly specify geometrical
arrangements of tissues and organs, and a process of encoding and decoding for …

The axolotl is one of the few tetrapods that are capable of regenerating complicated
biological structures, such as complete limbs, throughout adulthood. Upon injury the axolotl …

Mammals have extremely limited regenerative capabilities; however, axolotls are profoundly
regenerative and can replace entire limbs. The mechanisms underlying limb regeneration …

Evolutionary developmental biology, or Evo-Devo for short, has become an established field
that, broadly speaking, seeks to understand how changes in development drive major …

This review explores the historical and current state of our knowledge about urodele limb
regeneration. Topics discussed are (1) blastema formation by the proteolytic histolysis of …

Loss of regenerative capacity is a normal part of aging. However, some organisms, such as
the Mexican axolotl, retain striking regenerative capacity throughout their lives. Moreover …

The concept of positional information proposes that cells acquire positional values as in a
coordinate system, which they interpret by developing in particular ways to give rise to …

The mechanisms that regulate growth and size of the regenerating limb in tetrapods such as
the Mexican axolotl are unknown. Upon the completion of the developmental stages of …

Regeneration of missing body parts is an incredible ability which is present in a wide
number of species. However, this regenerative capability varies among different organisms …

While it is appreciated that global gene expression analyses can provide novel insights
about complex biological processes, experiments are generally insufficiently powered to …