The association between circadian clock gene polymorphisms and metabolic syndrome: a systematic review and meta-analysis

I Škrlec, J Talapko, S Džijan, V Cesar, N Lazić… - Biology, 2021 - mdpi.com
Simple Summary Metabolic syndrome is a cluster of cardio-metabolic risk factors and
comorbidities, including central obesity, hypertension, hyperglycemia, and dyslipidemia. In …

The cardiac circadian clock: implications for cardiovascular disease and its treatment

ME Young - Basic to Translational Science, 2023 - jacc.org
Virtually all aspects of physiology fluctuate with respect to the time of day. This is beautifully
exemplified by cardiovascular physiology, for which blood pressure and electrophysiology …

Cardiomyocyte-specific disruption of the circadian BMAL1–REV-ERBα/β regulatory network impacts distinct miRNA species in the murine heart

MN Latimer, LJ Williams, G Shanmugan… - Communications …, 2023 - nature.com
Circadian disruption increases cardiovascular disease (CVD) risk, through poorly
understood mechanisms. Given that small RNA species are critical modulators of cardiac …

The Impact of the Circadian Genes CLOCK and ARNTL on Myocardial Infarction

I Škrlec, J Milić, R Steiner - Journal of clinical medicine, 2020 - mdpi.com
The circadian rhythm regulates various physiological mechanisms, and its disruption can
promote many disorders. Disturbance of endogenous circadian rhythms enhances the …

Circadian de (regulation) in physiology: implications for disease and treatment

LVM de Assis, A Kramer - Genes & Development, 2024 - genesdev.cshlp.org
Time plays a crucial role in the regulation of physiological processes. Without a temporal
control system, animals would be unprepared for cyclic environmental changes, negatively …

Sex differences in circadian clock genes and myocardial infarction susceptibility

I Škrlec, J Talapko, M Juzbašić, R Steiner - Journal of cardiovascular …, 2021 - mdpi.com
The growing body of evidence shows a significant difference in the circadian rhythm of
cardiovascular disease based on biological sex. The incidence of cardiovascular disease …

Disturbance of suprachiasmatic nucleus function improves cardiac repair after myocardial infarction by IGF2-mediated macrophage transition

K Hao, Q Zhai, Y Gu, Y Chen, Y Wang, R Liu… - Acta Pharmacologica …, 2023 - nature.com
Suprachiasmatic nucleus (SCN) in mammals functions as the master circadian pacemaker
that coordinates temporal organization of physiological processes with the environmental …

The relationship between sleep, chronotype, and dental caries—a narrative review

A Kurtović, J Talapko, S Bekić, I Škrlec - Clocks & sleep, 2023 - mdpi.com
This article provides an overview of how sleep and circadian rhythm disturbances mutually
influence the occurrence of dental caries and how it is possible to reduce the risk of …

Myocardial Infarction Susceptibility and the MTNR1B Polymorphisms

I Škrlec, Z Biloglav, J Talapko, S Džijan… - International journal of …, 2023 - mdpi.com
Melatonin is a circadian hormone with antioxidant properties that protects against
myocardial ischemia-reperfusion injury. Genetic variations of the melatonin receptor 1B …

[HTML][HTML] Hepatitis B and circadian rhythm of the liver

I Skrlec, J Talapko - World journal of gastroenterology, 2022 - ncbi.nlm.nih.gov
The circadian rhythm in humans is determined by the central clock located in the
hypothalamus's suprachiasmatic nucleus, and it synchronizes the peripheral clocks in other …