Summary Apolipoprotein L1 (APOL1) genetic variants account for much of the excess risk of
chronic and end-stage kidney disease, which results in a significant global health disparity …

Rab GTPases are switched from their GDP-bound inactive conformation to a GTP-bound
active state by guanine nucleotide exchange factors (GEFs). The first putative GEFs isolated …

Sec1/Munc18 (SM) family proteins are essential for every vesicle fusion pathway. The best-
characterized SM protein is the synaptic factor Munc18-1, but it remains unclear whether its …

The fusion of neurotransmitter-filled synaptic vesicles with the plasma membrane requires
two classes of molecules—SNAP receptor (SNARE) and Sec1/Munc18 (SM) protein …

Intracellular vesicle fusion is mediated by SNAREs and Sec1/Munc18 (SM) proteins. Despite
intensive efforts, the SNARE-SM mediated vesicle fusion reaction has not been faithfully …

Abstract Background Mast cells utilize SNAREs (soluble-N-ethyl-maleimide sensitive factor
attachment protein receptors) and SM (Sec1/Munc18) proteins to secrete/exocytose a variety …

Tomosyn negatively regulates SNARE-dependent exocytic pathways including insulin
secretion, GLUT4 exocytosis, and neurotransmitter release. The molecular mechanism of …

Intracellular vesicle fusion requires the soluble N-ethylmaleimide-sensitive factor attachment
protein receptors (SNAREs) and their cognate Sec1/Munc18 (SM) proteins. How SM …

The vesicle fusion reaction in regulated exocytosis requires the concerted action of soluble
N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) core fusion engine …

The fusion of intracellular vesicles with target membranes is mediated by two classes of
conserved molecules—soluble N-ethylmaleimide-sensitive factor attachment protein …