COVID-19: Current understanding of its Pathophysiology, Clinical presentation and Treatment

A Parasher - Postgraduate medical journal, 2021 - academic.oup.com
Background The severe acute respiratory syndrome (SARS) coronavirus-2 is a novel
coronavirus belonging to the family Coronaviridae and is now known to be responsible for …

[HTML][HTML] The natural history, pathobiology, and clinical manifestations of SARS-CoV-2 infections

J Machhi, J Herskovitz, AM Senan, D Dutta… - Journal of neuroimmune …, 2020 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of
coronavirus disease 2019 (COVID-19). SARS-CoV-2, is a positive-sense single-stranded …

[HTML][HTML] SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract

YJ Hou, K Okuda, CE Edwards, DR Martinez… - Cell, 2020 - cell.com
The mode of acquisition and causes for the variable clinical spectrum of coronavirus disease
2019 (COVID-19) remain unknown. We utilized a reverse genetics system to generate a …

[HTML][HTML] Extrapulmonary manifestations of COVID-19

A Gupta, MV Madhavan, K Sehgal, N Nair… - Nature medicine, 2020 - nature.com
Although COVID-19 is most well known for causing substantial respiratory pathology, it can
also result in several extrapulmonary manifestations. These conditions include thrombotic …

Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study

L Carsana, A Sonzogni, A Nasr, RS Rossi… - The Lancet infectious …, 2020 - thelancet.com
Background COVID-19 is characterised by respiratory symptoms, which deteriorate into
respiratory failure in a substantial proportion of cases, requiring intensive care in up to a …

Factors associated with death in critically ill patients with coronavirus disease 2019 in the US

S Gupta, SS Hayek, W Wang, L Chan… - JAMA internal …, 2020 - jamanetwork.com
Importance The US is currently an epicenter of the coronavirus disease 2019 (COVID-19)
pandemic, yet few national data are available on patient characteristics, treatment, and …

Anticoagulation, bleeding, mortality, and pathology in hospitalized patients with COVID-19

GN Nadkarni, A Lala, E Bagiella, HL Chang… - Journal of the American …, 2020 - jacc.org
Background Thromboembolic disease is common in coronavirus disease-2019 (COVID-19).
There is limited evidence on the association of in-hospital anticoagulation (AC) with …

[HTML][HTML] The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection

S Pons, S Fodil, E Azoulay, L Zafrani - Critical care, 2020 - Springer
In severe SARS-CoV-2 infections, emerging data including recent histopathological studies
have emphasized the crucial role of endothelial cells (ECs) in vascular dysfunction …

Venous thromboembolism in COVID-19: A systematic review and meta-analysis

A Kollias, KG Kyriakoulis, S Lagou… - Vascular …, 2021 - journals.sagepub.com
Severe coronavirus disease 2019 (COVID-19) is associated with increased risk of venous
thromboembolism events (VTE). This study performed a systematic review in …

[HTML][HTML] Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review

Y Sakr, M Giovini, M Leone, G Pizzilli, A Kortgen… - Annals of intensive …, 2020 - Springer
Background Preliminary reports have described significant procoagulant events in patients
with coronavirus disease-2019 (COVID-19), including life-threatening pulmonary embolism …