[HTML][HTML] Cocaine: an updated overview on chemistry, detection, biokinetics, and pharmacotoxicological aspects including abuse pattern

R Roque Bravo, AC Faria, AM Brito-da-Costa, H Carmo… - Toxins, 2022 - mdpi.com
Cocaine is one of the most consumed stimulants throughout the world, as official sources
report. It is a naturally occurring sympathomimetic tropane alkaloid derived from the leaves …

[HTML][HTML] Cocaine: an updated overview on chemistry, detection, biokinetics, and pharmacotoxicological aspects including abuse pattern

RR Bravo, AC Faria, AM Brito-da-Costa, H Carmo… - Toxins, 2022 - ncbi.nlm.nih.gov
Cocaine is one of the most consumed stimulants throughout the world, as official sources
report. It is a naturally occurring sympathomimetic tropane alkaloid derived from the leaves …

Melatonin attenuates fentanyl-induced behavioral sensitization and circadian rhythm disorders in mice

K Du, Q Shi, X Zhou, L Zhang, H Su, C Zhang… - Physiology & …, 2024 - Elsevier
Melatonin is a neurohormone synthesized by the pineal gland to regulate the circadian
rhythms and has proven to be effective in treating drug addiction and dependence …

[HTML][HTML] Melatonin blocks morphine-induced place preference: involvement of GLT-1, NF-κB, BDNF, and CREB in the nucleus accumbens

BS Alghamdi, FS Alshehri - Frontiers in Behavioral Neuroscience, 2021 - frontiersin.org
Opioid addiction remains a widespread issue despite continuous attempts by the FDA to
help maintain abstinence. Melatonin is a neurohormone considered to be involved only in …

[PDF][PDF] on behalf of The OEMONOM Researchers. Cocaine: An Updated Overview on Chemistry, Detection, Biokinetics, and Pharmacotoxicological Aspects including …

R Roque Bravo, AC Faria, AM Brito-da-Costa, H Carmo… - 2022 - academia.edu
Cocaine is one of the most consumed stimulants throughout the world, as official sources
report. It is a naturally occurring sympathomimetic tropane alkaloid derived from the leaves …

[HTML][HTML] Identification of key genes and therapeutic drugs for cocaine addiction using integrated bioinformatics analysis

X Wang, S Sun, H Chen, B Yun, Z Zhang… - Frontiers in …, 2023 - frontiersin.org
Introduction Cocaine is a highly addictive drug that is abused due to its excitatory effect on
the central nervous system. It is critical to reveal the mechanisms of cocaine addiction and …

Effects of the GluN2B-selective antagonist Ro 63-1908 on acquisition and expression of methamphetamine conditioned place preference in male and female rats

JR Yates, HL Campbell, LL Hawley, MJ Horchar… - Drug and alcohol …, 2021 - Elsevier
Background Methamphetamine abuse has increased significantly in recent years. Currently,
there are no FDA-approved pharmacotherapies for the treatment of methamphetamine use …

COT-TT vaccine attenuates cocaine-seeking and cocaine-conditioned place preference in rats

S Barbosa-Méndez, M Matus-Ortega… - Human Vaccines & …, 2024 - Taylor & Francis
Vaccination active, promising alternative immunological strategy to treat of CUD. Various
models of cocaine vaccines have been evaluated in animals and humans with relative …

[HTML][HTML] Role of melatonin in the management of substance addiction: a systematic review

A Das, M Prithviraj, PS Mohanraj - Cureus, 2022 - ncbi.nlm.nih.gov
Recent evidence links melatonin hormone and its receptor to the etiology and behavioral
manifestation of addiction. The role of exogenous melatonin in addiction treatment is still …

[HTML][HTML] Brain systems in cocaine abstinence-induced anxiety-like behavior in rodents: a review

BR Barbee, SL Gourley - Addiction neuroscience, 2022 - Elsevier
Cocaine use disorder (CUD) is a significant public health issue that generates substantial
personal, familial, and economic burdens. Still, there are no FDA-approved …