Modeling autism-relevant behavioral phenotypes in rats and mice: Do 'autistic'rodents exist?

M Servadio, LJMJ Vanderschuren… - Behavioural …, 2015 - journals.lww.com
Autism spectrum disorders (ASD) are among the most severe developmental psychiatric
disorders known today, characterized by impairments in communication and social …

Acetylcholine elevation relieves cognitive rigidity and social deficiency in a mouse model of autism

G Karvat, T Kimchi - Neuropsychopharmacology, 2014 - nature.com
Autism spectrum disorders (ASD) are defined by behavioral deficits in social interaction and
communication, repetitive stereotyped behaviors, and restricted interests/cognitive rigidity …

Polyphenols as food bioactive compounds in the context of Autism Spectrum Disorders: A critical mini-review

D Serra, LM Almeida, TCP Dinis - Neuroscience & Biobehavioral Reviews, 2019 - Elsevier
Dietary polyphenols are bioactive compounds with potential in preventing and treating
several chronic disorders, mainly due to their ability to modulate key pro-inflammatory and …

Mesenchymal stem cell transplantation promotes neurogenesis and ameliorates autism related behaviors in BTBR mice

H Segal‐Gavish, G Karvat, N Barak, R Barzilay… - Autism …, 2016 - Wiley Online Library
Autism spectrum disorders (ASD) are characterized by social communication deficits,
cognitive rigidity, and repetitive stereotyped behaviors. Mesenchymal stem cells (MSC) have …

Adenosine A2A receptor modulates neuroimmune function through Th17/retinoid-related orphan receptor gamma t (RORγt) signaling in a BTBR T+ Itpr3tf/J mouse …

MA Ansari, A Nadeem, SM Attia, SA Bakheet, M Raish… - Cellular …, 2017 - Elsevier
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized
by abnormal social interactions, repetitive behaviors that impair social communication, and …

Cerebellar oxidative DNA damage and altered DNA methylation in the BTBR T+ tf/J mouse model of autism and similarities with human post mortem cerebellum

S Shpyleva, S Ivanovsky, A de Conti, S Melnyk… - PloS one, 2014 - journals.plos.org
The molecular pathogenesis of autism is complex and involves numerous genomic,
epigenomic, proteomic, metabolic, and physiological alterations. Elucidating and …

Activation of adenosine A2A receptor signaling regulates the expression of cytokines associated with immunologic dysfunction in BTBR T+ Itpr3tf/J mice

MA Ansari, SM Attia, A Nadeem, SA Bakheet… - Molecular and Cellular …, 2017 - Elsevier
Autism spectrum disorder (ASD) is neurodevelopmental disorders characterized by
stereotypical repetitive behavior, impaired social interaction, and deficits in communication …

Lipopolysaccharide-induced maternal immune activation modulates microglial CX3CR1 protein expression and morphological phenotype in the hippocampus and …

LF de Cossío, C Lacabanne, M Bordeleau… - Brain, Behavior, and …, 2021 - Elsevier
Inflammation during pregnancy can disturb brain development and lead to disorders in the
progeny, including autism spectrum disorder and schizophrenia. However, the mechanism …

The PPARδ agonist GW0742 restores neuroimmune function by regulating Tim-3 and Th17/Treg-related signaling in the BTBR autistic mouse model

SF Ahmad, A Nadeem, MA Ansari, SA Bakheet… - Neurochemistry …, 2018 - Elsevier
Autism spectrum disorders (ASD) are neurodevelopmental disorders that are characterized
by repetitive behaviors, and impairments in communication and social interaction. Studies …

The Role of Nicotinic Receptors in the Attenuation of Autism‐Related Behaviors in a Murine BTBR T+ tf/J Autistic Model

HM Mahmood, HM Aldhalaan, TK Alshammari… - Autism …, 2020 - Wiley Online Library
Nicotinic receptors are distributed throughout the central and peripheral nervous system.
Postmortem studies have reported that some nicotinic receptor subtypes are altered in the …